Sandbox : anmol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2]

Differential NHL

Diseases			Clinical manifestations						Para-clinical findings			Pathogonomic finding
			Symptoms
									Lab Findings	Images	Biopsy Histopathology
			Lymphadenopathy	Fever	Weight loss	Night Sweats	Rash	Other symptoms	Lab 1	Imaging 1
Non-Hodgkins lymphoma			painless localized or generalized	+	+	+	+	Presents with "B" symptoms Constant fatigue Shortness of breath and Cough Abdominal pain or swelling Constipation Nausea andvomiting.
INFECTIONS	Bacteria	Syphilis	painless localized	+	-	-	+	Primary syphilis: Chancer Secondary syphilis: Rash Condylomata lata Patchy alopecia Tertiary syphilis Gumma Organ system involvement	Darkfield microscopy to detect T. pallidum. Nontreponemal tests (e.g., VDRLand RPR ) Treponemal tests (e.g. FTA-ABS, the TP-PA assay			Painless clean base chancre.
		Brucellosis	Painful	+	-	-	+	Abdominal pain hepatosplenomegaly arthritis	Brucella is most commonly isolated from blood cultures positive titer of anti-brucella antibodies on serological testing			Night sweats, often with characteristic smell, likened to wet hay
	Viral	infectious mononucleosis	painful	+	-	-	+	low-grade feverwithout chills sore throat, white patches on tonsils and back of the throat, muscle weakness fatigue petechial hemorrhage
		CMV		+	-	-	+
		HIV	Painful or painless	-	+	-	-
		Cat scratch disease		+	-	-	+
	Mycobacteria	Tuberculosis	Painful	+	+	+	+	Prior history of residence in an endemic area. Chronic cough, weight loss, hemoptysis	PCR of CSF for tuberculosis Mycobacterial culture of CSF Brain biopsy for acid-fast bacilli staining Culture and acid stain positive for acid-fast bacilli CXR shows cavitations.			Gohn's focus
	Parasite	Toxoplasmosis			-	-
Diseases			Lymphadenopathy	Fever	Weight loss	Night sweats	Rash	Other symptoms	Lab 1	Imaging 1	Biopsy Histopathology	Pathogonomical findings
AUTOIMMUNE	Systemic lupus erythematosus		painless	-	-	-	+		ESR CRPelevated ANA positive			Malar rash and photosensitivity
	Sjögren's syndrome		Painless	-	-	-	+	Xerosis Scaly skin Annular erythema				Keratoconjunctivitis sicca
	Sarcoidosis		painless	-	-	-								-	-
Diseases			Lymphadenopathy	Fever	Weight loss	Night sweats	Rash	Other symptoms	Lab 1	Imaging 1	Biopsy Histopathology	Pathogonomical findings
NEOPLASIA	Hodgkin's disease		painless	-	-	-	+		ESR CRPelevated ANA positive			Malar rash and photosensitivity
	Chronic lymphocytic leukemia		Painless	-	-	-	+	Xerosis Scaly skin Annular erythema				Keratoconjunctivitis sicca
	Small cell carcinoma of the lung		painless	-	-	-
	Melanoma		painless	-	-	-
	Lymphomatoid granulomatosis		painless	-	-	-
	Angioimmunoblastic lymphadenopathy		painless	-	-	-
NEOPLASIA	Giant lymph node hyperplasia (Castleman disease)		painless	-	-	-