Amyloidosis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[3]
Overview
Laboratory findings depend on the organs involved. Laboratory testing of specific organs can reveal dysfunction, and the degree of laboratory derangement is usually related to the extent of amyloid involvement.
Laboratory Findings
- Cardiac: Cardiac biomarkers are the most important predictors of outcome in amyloidosis and provide a quantitative assessment for:[1]
- Cardiac damage (Troponin I or Troponin T)
- Wall strain (BNP and NT-proBNP)
- Hepatic: Liver functions tests include:
- AST
- ALT
- Total bilirubin
- Alkaline phosphatase
- Albumin
- Renal: A variety of kidney function tests can suggest amyloidosis. These include abnormalities in:
- Serum creatinine
- Urinary protein
- Glomerular filtration rate
- Albumin to creatinine ratio in the urine
- Thyroid: Common tests that are abnormal in thyroidal involvement of amyloidosis include:
- TSH
- Free T4
References
- ↑ Merlini G, Seldin DC, Gertz MA (May 2011). "Amyloidosis: pathogenesis and new therapeutic options". J. Clin. Oncol. 29 (14): 1924–33. doi:10.1200/JCO.2010.32.2271. PMC 3138545. PMID 21483018.