Non small cell lung cancer historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Trusha Tank, M.D.[2] Maria Fernanda Villarreal, M.D. [3]
Overview
In 1879, Harting and Hesse, two German physicians, first described the association between lung cancer and working in mines. In 1929, Fritz Lickint a German physician first described the association between smoking and non-small cell lung cancer.
Historical Perspective
- In 1929, Fritz Lickint a German physician first described the association between smoking and non-small cell lung cancer.
- In 1761 Dr. John Hill, of London proved the relationship between the use of tobacco and cancer in his case study.
- In 1879, Harting and Hesse, two German physicians, first described the association between lung cancer and working in mines.
- In 1929, Fritz Lickint a German physician first described the association between smoking and non small cell lung cancer.
- In 1950, "The British Doctors Study" was the first solid epidemiological evidence of the link between lung cancer and smoking.
- In 1966, the first preventive measures against lung cancer were implemented, warning labels first appeared on cigarette packs "Caution: Cigarette Smoking May Be Hazardous to Your Health".*In 1982, Geoffrey Cooper, an American pathologist first used the NIH 3T3 focus assay to identify the activated K-ras oncogene in lung cancer cell lines.
- In 1986, the association between second-hand smoking and non small cell lung cancer was established.
- In 1987, it was established that a receptor on cancer cells called the epidermal growth factor receptor (EGFR) plays an important role in the growth and spread of non small cell lung cancer.