Mucoepidermoid carcinoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Badria Munir M.B.B.S.[2] Maria Fernanda Villarreal, M.D. [3]

Overview

Mucoepidermoid carcinoma may be classified according to location into 2 subtypes: salivary gland-confined carcinomas and other organ mucoepidermoid carcinomas.

Classification

Mucoepidermoid carcinoma may be classified according to location into 2 subtypes:

Classification: Mucoepidermoid Carcinomas Adapted from Radiopedia
Salivary gland-confined carcinomas	Major salivary glands (50%)	Parotid gland (40%) Submandibular gland (7%) Sublingual gland (3%)
	Minor salivary glands (50%)	Palate (most common) Retromolar area Floor of the mouth Buccal mucosa Lip Tongue
Other organ mucoepidermoid carcinomas	Thyroid Lung

Grading based on Histopathology:

• Mucoepidermoid carcinoma are graded into three subtypes based on histpathological features:
  • Low
  • Intermediate
  • High grade
• The three most popular grading systems are:
  • the AFIP grading system [21],
  • modified Healey system [22], and
  • The Brandwein [23] system (Table 5).
• All categories are based on similar set of parameters which include both cytomorphologic and architectural, particularly perineural and angiolymphatic invasion.