MIR187

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

MicroRNA 187 is a protein that in humans is encoded by the MIR187 gene.

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

Further reading

• Rossato, M.; Curtale, G.; Tamassia, N.; Castellucci, M.; Mori, L.; Gasperini, S.; Mariotti, B.; De Luca, M.; Mirolo, M.; Cassatella, M. A.; Locati, M.; Bazzoni, F. (2012). "IL-10-induced microRNA-187 negatively regulates TNF- , IL-6, and IL-12p40 production in TLR4-stimulated monocytes". Proceedings of the National Academy of Sciences. 109 (45): E3101–E3110. doi:10.1073/pnas.1209100109. PMC 3494907. PMID 23071313.
• Lim, L. P.; Glasner, M. E.; Yekta, S.; Burge, C. B.; Bartel, D. P. (2003). "Vertebrate MicroRNA Genes". Science. 299 (5612): 1540. doi:10.1126/science.1080372. PMID 12624257.
• Dostie, J.; Mourelatos, Z.; Yang, M.; Sharma, A.; Dreyfuss, G. (2003). "Numerous microRNPs in neuronal cells containing novel microRNAs". RNA. 9 (2): 180–186. doi:10.1261/rna.2141503. PMC 1370383. PMID 12554860.
• Chao, A.; Lin, C. -Y.; Lee, Y. -S.; Tsai, C. -L.; Wei, P. -C.; Hsueh, S.; Wu, T. -I.; Tsai, C. -N.; Wang, C. -J.; Chao, A. -S.; Wang, T. -H.; Lai, C. -H. (2011). "Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2". Oncogene. 31 (6): 764–775. doi:10.1038/onc.2011.269. PMID 21725366.
• Mulrane, L.; Madden, S. F.; Brennan, D. J.; Gremel, G.; McGee, S. F.; McNally, S.; Martin, F.; Crown, J. P.; Jirström, K.; Higgins, D. G.; Gallagher, W. M.; O'Connor, D. P. (2012). "MiR-187 is an Independent Prognostic Factor in Breast Cancer and Confers Increased Invasive Potential in Vitro". Clinical Cancer Research. 18 (24): 6702–6713. doi:10.1158/1078-0432.CCR-12-1420. PMID 23060431.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.