Serine/threonine-protein kinase 24 is an enzyme that in humans is encoded by the STK24gene.[1][2][3]
The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000).[supplied by OMIM][3]
↑Schinkmann K, Blenis J (Dec 1997). "Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements". J Biol Chem. 272 (45): 28695–703. doi:10.1074/jbc.272.45.28695. PMID9353338.
↑Zhou TH, Ling K, Guo J, Zhou H, Wu YL, Jing Q, Ma L, Pei G (Feb 2000). "Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase". J Biol Chem. 275 (4): 2513–9. doi:10.1074/jbc.275.4.2513. PMID10644707.
↑Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. England. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.
Christian SL, McDonough J, Liu Cy CY, et al. (2002). "An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia". Genomics. 79 (5): 635–56. doi:10.1006/geno.2002.6765. PMID11991713.
Huang CY, Wu YM, Hsu CY, et al. (2002). "Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis". J. Biol. Chem. 277 (37): 34367–74. doi:10.1074/jbc.M202468200. PMID12107159.
Lee WS, Hsu CY, Wang PL, et al. (2004). "Identification and characterization of the nuclear import and export signals of the mammalian Ste20-like protein kinase 3". FEBS Lett. 572 (1–3): 41–5. doi:10.1016/j.febslet.2004.07.007. PMID15304321.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.
Lu TJ, Lai WY, Huang CY, et al. (2007). "Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST". J. Biol. Chem. 281 (50): 38405–17. doi:10.1074/jbc.M605035200. PMID17046825.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID17081983.
