Zinc finger protein 280B is a protein that in humans is encoded by the ZNF280B gene.
[1]
Function
The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancercells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding.Interestingly, the ZNF208B gene is localized between the variable subgenes for light chain of immunoglobulins (Ig), and it is lost in B cells that rearrange specific lambda variable Ig subgenes [2]
↑Mraz, M; Stano Kozubik, K; Plevova, K; Musilova, K; Tichy, B; Borsky, M; Kuglik, P; Doubek, M; Brychtova, Y; Mayer, J; Pospisilova, S (2013). "The origin of deletion 22q11 in chronic lymphocytic leukemia is related to the rearrangement of immunoglobulin lambda light chain locus". Leuk Res. 37: 802–8. doi:10.1016/j.leukres.2013.03.018. PMID23608880.
