KIAA1958

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VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein KIAA1958 is a protein that in humans is encoded by the KIAA1958 gene.[1] Orthologs of KIAA1958 go as far back in evolution to chordates, although, it is closer in homology to primates than any other orthologs. KIAA1958 has no known paralogs.

Gene

KIAA1958 is located on the long arm of chromosome 9 (9.q32) in humans on the plus strand from 115249248 to 115427597.[2] Its mRNA has 2683 bp.[1] The gene has these neighbors on chromosome 9:

File:KIAA1958 neighboring genes on both sides.jpg
KIAA1958 gene neighbors

HSDL2: Hydroxysteroid dehydrogenase-like protein 2 plays a role in nucleotide binding, oxidoreductase activity, and sterol binding.[3]

C9orf147: Chromosome 9 open reading frame 147 has an unknown function.[4]

C9orf80: Chromosome 9 open reading frame 80 is a component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell cycle checkpoint activation, recombinational repair and maintenance of genomic stability.[5]

SNX30: Sorting nexin-30 may be linked to phosphatidylinositol binding.[6]

Expression

KIAA1958 is expressed in the highest quantities in the larynx as proposed by EST.[7] The highest expression in developmental stage is the blastocyst and for health state, it is most found in uterine tumors.[7] Data from NCBI GEO Profile[8] shows that KIAA1958 expression includes many of the tissue types in the human body. Using EMBL-EBI, KIAA1958 was found to be overexpressed in pseudopod RNA during the migration of the metastatic cancer cells.[9] KIAA1958 was also overexpressed in Stat5/ab and stat 3 which are transcription factors reported to be critical for the growth and viability of prostate cancer cells[9] and both the embryonic stem cell and the pluripotent stem cell.[9]

Protein

File:KIAA1958 phosphorylated serines.jpg
KIAA1958 predicted phosphorylated sites

KIAA1958 is composed of 716 amino acids and weighs 79212 Da with an iso-electric point of 6.375.[10] Although not much is known about the KIAA1958 protein, scientific predictions have been made using supercomputers for predictions of KIAA1958's structure and function. KIAA1958 undergoes post-translational modifications. The most interesting modification is phosphorylation. In comparison to other proteins, KIAA1958 has a substantially significant amount of serines phosphorylated during post-translational modification. 36 serines are predicted to be phosphorylated.

Structure

PELE on SDSC Biology WorkBench is supercomputer that is able to predict secondary structure of the KIAA1958 protein.[11] According to this tool, the protein's secondary structure is a combination of alpha helices and beta sheets, in almost equal amount and spread out almost evenly throughout the protein.

Interactions

There is no known proof that KIAA1958 interacts with any other proteins at this time.[12]

Homology

Genus and Species Common Name Accession Number Seq. Length Seq. Identity Seq. Similarity
Pan troglodytes Chimpanzee XM_528391 7945 bp 99% 99%
Mus musculus Mouse BAC38268 719 a 97% 98%
Callithrix jacchus Common marmoset XM_002743204 2346bp 97% 82%
Pongo abelii Sumatran Orangutan XM_002820112 1120bp 96% 4%
Sus scrofa Wild boar XM_003122070 2502 bp 93% 81%
Ailuropoda melanoleuca Giant Panda XM_002925938 2151 bp 85% 91%
Nomascus leucogenys White cheeked gibbon XM_003263945 950 bp 93% 5%
Oryctolagus cuniculus European rabbit XM_002707990 2223 bp 93% 43%
Loxodonta africana African bush elephant XM_003407521 2388 bp 93% 80%
Cricetulus griseus Chinese hamster XM_003505508 2534 bp 92% 42%
Equus caballus Horse XM_001916302 2536 bp 91% 93%
Bos taurus Cow XM_876102.5 2480 bp 91% 81%
Rattus norvegicus Rat XM_002726532 1364 bp 91% 36%
Cavia porcellus Guinea pig XM_003463791 2217 bp 91% 43%
Monodelphis domestica Opossum XM_001375976 2217 bp 78% 41%
Branchiostoma floridae Lancelet XP_002611438 719 a 29% 48%
Amphimedon queenslandica Sponge XP_003390994 388 a 25% 48%
Acyrthosiphon pisum Pea aphid XP_001943720 1197 aa 24% 43%
Oikopleura dioica Chordate CBY34656 629 a 22% 43%
Ciona intestinalis Vase tunicate XP_002125964 1004 aa 23% 43%
Xenopus (silurana) tropicalis Western Clawed frog AAI61073 679 a 23% 43%
Halocynthia roretzi Sea pineapple BAB40645 980 a 23% 45%

References

  1. 1.0 1.1 "Homo sapiens KIAA1958 (KIAA1958), mRNA". NCBI. Retrieved 20 April 2012.
  2. "Homo sapiens gene KIAA1958, encoding KIAA1958". AceView. Retrieved 19 April 2012.
  3. "Q6YN16 (HSDL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot". UniProt. Retrieved 1 May 2012.
  4. "Homo sapiens gene C9orf147, encoding chromosome 9 open reading frame 147". AceView. Retrieved 1 May 2012.
  5. "Q9NRY2 (SOSSC_HUMAN) Reviewed, UniProtKB/Swiss-Prot". Retrieved 1 May 2012.
  6. "Q5VWJ9 (SNX30_HUMAN) Reviewed, UniProtKB/Swiss-Prot". Retrieved 1 May 2012.
  7. 7.0 7.1 "Unigene EST profile". Unigene. Retrieved 8 May 2012.
  8. "Geo Profiles". NCBI. Retrieved 28 April 2012.
  9. 9.0 9.1 9.2 "Gene Expression Profiles". Embl-Ebi. Retrieved 8 May 2012.
  10. "Biology WorkBench". SDSC. Retrieved 3 May 2012.
  11. "Biology Workbench". SDSC Biology WorkBench. Retrieved 28 April 2012.
  12. "Protein Interactions". String. Retrieved 7 May 2012.

Further reading

  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.