The ASRGL1 protein consists of 308 amino acids and is activated by autocleavage at amino acid 168 to form an alpha- and a beta-chain, which can dimerize into a heterodimer.[2] The ASRGL1 enzyme has both L-asparaginase and beta-aspartyl peptidase activity and may be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions.
According to antibody-based profiling and transcriptomics analysis, ASRGL1 protein is present in all analysed human tissues, with highest expression in female tissues such as the uterine cervix and fallopian tube, and in male tissues ASRGL1 is highest expressed in the testis.[3] Based on confocal microscopy ASRGL1 is mainly localized to the microtubules.[4]
Clinical significance
ASRGL1 is highly expressed in the normal endometrium and differentially expressed in endometrial cancer. Loss of ASRGL1 expression is an unfavorable prognostic feature for patients with endometrial cancer.[5][6]
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