DNA polymerase subunit gamma-2, mitochondrial is an protein that in humans is encoded by the POLG2gene. The POLG2 gene encodes a 55 kDa accessory subunit protein that imparts high processivity and salt tolerance to the catalytic subunit of DNA polymerase gamma, encoded by the POLG gene.[1][2][3]
References
↑Wang Y, Farr CL, Kaguni LS (Jul 1997). "Accessory subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, molecular analysis, and association in the native enzyme". J Biol Chem. 272 (21): 13640–6. doi:10.1074/jbc.272.21.13640. PMID9153213.
↑Lim SE, Longley MJ, Copeland WC (1999). "The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance". J. Biol. Chem. 274 (53): 38197–203. doi:10.1074/jbc.274.53.38197. PMID10608893.
Further reading
Michiels S, Danoy P, Dessen P, et al. (2007). "Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers". Carcinogenesis. 28 (8): 1731–9. doi:10.1093/carcin/bgm111. PMID17494052.
Huang H, Shiffman ML, Cheung RC, et al. (2006). "Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C.". Gastroenterology. 130 (6): 1679–87. doi:10.1053/j.gastro.2006.02.032. PMID16697732.
Yakubovskaya E, Chen Z, Carrodeguas JA, et al. (2006). "Functional human mitochondrial DNA polymerase gamma forms a heterotrimer". J. Biol. Chem. 281 (1): 374–82. doi:10.1074/jbc.M509730200. PMID16263719.
Carrodeguas JA, Pinz KG, Bogenhagen DF (2003). "DNA binding properties of human pol gammaB". J. Biol. Chem. 277 (51): 50008–14. doi:10.1074/jbc.M207030200. PMID12379656.
Johnson AA, Tsai Y, Graves SW, Johnson KA (2000). "Human mitochondrial DNA polymerase holoenzyme: reconstitution and characterization". Biochemistry. 39 (7): 1702–8. doi:10.1021/bi992104w. PMID10677218.
Lim SE, Longley MJ, Copeland WC (1999). "The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance". J. Biol. Chem. 274 (53): 38197–203. doi:10.1074/jbc.274.53.38197. PMID10608893.