RAP1GAP2

VALUE_ERROR (nil)
Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

RAP1 GTPase activating protein 2 is a protein in humans that is encoded by the RAP1GAP2 gene.

This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

Further reading

• Neumuller, O.; Hoffmeister, M.; Babica, J.; Prelle, C.; Gegenbauer, K.; Smolenski, A. P. (2009). "Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets". Blood. 114 (7): 1396–1404. doi:10.1182/blood-2008-05-155234. PMID 19528539.
• Aouizerat, B. E.; Vittinghoff, E.; Musone, S. L.; Pawlikowska, L.; Kwok, P. Y.; Olgin, J. E.; Tseng, Z. H. (2011). "GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease". BMC Cardiovascular Disorders. 11: 29. doi:10.1186/1471-2261-11-29. PMC 3141757. PMID 21658281.
• Balduini, A.; Pecci, A.; Lova, P.; Arezzi, N.; Marseglia, C.; Bellora, F.; Perotti, C.; Balduini, C.; Balduini, C. L.; Torti, M. (2004). "Expression, activation, and subcellular localization of the Rap1 GTPase in cord blood-derived human megakaryocytes". Experimental Cell Research. 300 (1): 84–93. doi:10.1016/j.yexcr.2004.07.011. PMID 15383317.
• Kimura, T.; Mogi, C.; Sato, K.; Tomura, H.; Ohta, H.; Im, D. -S.; Kuwabara, A.; Kurose, H.; Murakami, M.; Okajima, F. (2011). "P2y5/LPA6 attenuates LPA1-mediated VE-cadherin translocation and cell-cell dissociation through G12/13 protein-Src-Rap1". Cardiovascular Research. 92 (1): 149–158. doi:10.1093/cvr/cvr154. PMID 21632882.
• Schultess, J.; Danielewski, O.; Smolenski, A. P. (2005). "Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets". Blood. 105 (8): 3185–3192. doi:10.1182/blood-2004-09-3605. PMID 15632203.
• Hoffmeister, M.; Riha, P.; Neumuller, O.; Danielewski, O.; Schultess, J.; Smolenski, A. P. (2007). "Cyclic Nucleotide-dependent Protein Kinases Inhibit Binding of 14-3-3 to the GTPase-activating Protein Rap1GAP2 in Platelets". Journal of Biological Chemistry. 283 (4): 2297–2306. doi:10.1074/jbc.M706825200. PMID 18039662.