XRCC1

X-ray repair complementing defective repair in Chinese hamster cells 1
File:PBB Protein XRCC1 image.jpg PDB rendering based on 1cdz.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1cdz​, 1xna​, 1xnt​, 2d8m​
Identifiers
Symbols	XRCC1 ; RCC
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31368
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE XRCC1 203655 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

XRCC1 is a DNA repair protein.

It complexes with DNA ligase III.

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Further reading

• Hung RJ, Hall J, Brennan P, Boffetta P (2006). "Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review". Am. J. Epidemiol. 162 (10): 925–42. doi:10.1093/aje/kwi318. PMID 16221808.CS1 maint: Multiple names: authors list (link)
• Thompson LH, Brookman KW, Jones NJ; et al. (1991). "Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange". Mol. Cell. Biol. 10 (12): 6160–71. PMID 2247054.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thompson LH, Bachinski LL, Stallings RL; et al. (1990). "Complementation of repair gene mutations on the hemizygous chromosome 9 in CHO: a third repair gene on human chromosome 19". Genomics. 5 (4): 670–9. PMID 2591959.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gyapay G, Morissette J, Vignal A; et al. (1994). "The 1993-94 Généthon human genetic linkage map". Nat. Genet. 7 (2 Spec No): 246–339. doi:10.1038/ng0694supp-246. PMID 7545953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wei Q, Xu X, Cheng L; et al. (1995). "Simultaneous amplification of four DNA repair genes and beta-actin in human lymphocytes by multiplex reverse transcriptase-PCR". Cancer Res. 55 (21): 5025–9. PMID 7585546.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lamerdin JE, Montgomery MA, Stilwagen SA; et al. (1995). "Genomic sequence comparison of the human and mouse XRCC1 DNA repair gene regions". Genomics. 25 (2): 547–54. PMID 7789989.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Caldecott KW, McKeown CK, Tucker JD; et al. (1994). "An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III". Mol. Cell. Biol. 14 (1): 68–76. PMID 8264637.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Trask B, Fertitta A, Christensen M; et al. (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics. 15 (1): 133–45. PMID 8432525.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kubota Y, Nash RA, Klungland A; et al. (1997). "Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein". EMBO J. 15 (23): 6662–70. PMID 8978692.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nash RA, Caldecott KW, Barnes DE, Lindahl T (1997). "XRCC1 protein interacts with one of two distinct forms of DNA ligase III". Biochemistry. 36 (17): 5207–11. doi:10.1021/bi962281m. PMID 9136882.CS1 maint: Multiple names: authors list (link)
• Shen MR, Jones IM, Mohrenweiser H (1998). "Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans". Cancer Res. 58 (4): 604–8. PMID 9485007.CS1 maint: Multiple names: authors list (link)
• Price EA, Bourne SL, Radbourne R; et al. (1998). "Rare microsatellite polymorphisms in the DNA repair genes XRCC1, XRCC3 and XRCC5 associated with cancer in patients of varying radiosensitivity". Somat. Cell Mol. Genet. 23 (4): 237–47. PMID 9542526.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Masson M, Niedergang C, Schreiber V; et al. (1998). "XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage". Mol. Cell. Biol. 18 (6): 3563–71. PMID 9584196.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taylor RM, Wickstead B, Cronin S, Caldecott KW (1998). "Role of a BRCT domain in the interaction of DNA ligase III-alpha with the DNA repair protein XRCC1". Curr. Biol. 8 (15): 877–80. PMID 9705932.CS1 maint: Multiple names: authors list (link)
• Zhou ZQ, Walter CA (1998). "Cloning and characterization of the promoter of baboon XRCC1, a gene involved in DNA strand-break repair". Somat. Cell Mol. Genet. 24 (1): 23–39. PMID 9776979.
• Taylor RM, Moore DJ, Whitehouse J; et al. (2000). "A cell cycle-specific requirement for the XRCC1 BRCT II domain during mammalian DNA strand break repair". Mol. Cell. Biol. 20 (2): 735–40. PMID 10611252.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marintchev A, Robertson A, Dimitriadis EK; et al. (2000). "Domain specific interaction in the XRCC1-DNA polymerase beta complex". Nucleic Acids Res. 28 (10): 2049–59. PMID 10773072.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Duell EJ, Wiencke JK, Cheng TJ; et al. (2000). "Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells". Carcinogenesis. 21 (5): 965–71. PMID 10783319.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Whitehouse CJ, Taylor RM, Thistlethwaite A; et al. (2001). "XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair". Cell. 104 (1): 107–17. PMID 11163244.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dulic A, Bates PA, Zhang X; et al. (2001). "BRCT domain interactions in the heterodimeric DNA repair protein XRCC1-DNA ligase III". Biochemistry. 40 (20): 5906–13. PMID 11352725.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• X-ray+repair+cross+complementing+protein+1 at the US National Library of Medicine Medical Subject Headings (MeSH)