Dihydroorotase
| carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | |
|---|---|
| File:4by3.jpg Dihydroorotase (fragment) dimer, Human | |
| Identifiers | |
| Symbol | CAD |
| Entrez | 790 |
| HUGO | 1424 |
| OMIM | 114010 |
| RefSeq | NM_004341 |
| UniProt | P27708 |
| Other data | |
| EC number | 3.5.2.3 |
| Locus | Chr. 2 p22-p21 |
Dihydroorotase (EC 3.5.2.3, carbamoylaspartic dehydrase, dihydroorotate hydrolase) is an enzyme which converts carbamoyl aspartic acid into 4,5-dihydroorotic acid in the biosynthesis of pyrimidines.[1][2] It forms a multifunctional enzyme with carbamoyl phosphate synthetase and aspartate transcarboymalase.
See also
References
- ↑ Cooper, C.; Wilson, D.W. (1954). "Biosynthesis of pyrimidines". Fed. Proc. 13: 194–194.
- ↑ Lieberman, I.; Kornberg, A. (1954). "Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. II. Dihydroorotic acid, ureidosuccinic acid, and 5-carboxymethylhydantoin" (PDF). J. Biol. Chem. 207: 911–924. PMID 13163076.
External links
- Dihydroorotase at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 3.5.2.3
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