POLQ

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

DNA polymerase theta is an enzyme that in humans is encoded by the POLQ gene.

Further reading

• Hogg M, Sauer-Eriksson AE, Johansson E (2012). "Promiscuous DNA synthesis by human DNA polymerase θ." Nucleic Acids Research. 40 (6): 2611–2622. doi:10.1093/nar/gkr1102. PMC 3315306. PMID 22135286.
• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
• Maga G, Shevelev I, Ramadan K, et al. (2002). "DNA polymerase theta purified from human cells is a high-fidelity enzyme". J. Mol. Biol. 319 (2): 359–69. doi:10.1016/S0022-2836(02)00325-X. PMID 12051913.
• Seki M, Marini F, Wood RD (2003). "POLQ (Pol θ), a DNA polymerase and DNA-dependent ATPase in human cells". Nucleic Acids Res. 31 (21): 6117–26. doi:10.1093/nar/gkg814. PMC 275456. PMID 14576298.
• Kawamura K, Bahar R, Seimiya M, et al. (2004). "DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers". Int. J. Cancer. 109 (1): 9–16. doi:10.1002/ijc.11666. PMID 14735462.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Seki M, Masutani C, Yang LW, et al. (2005). "High-efficiency bypass of DNA damage by human DNA polymerase Q". EMBO J. 23 (22): 4484–94. doi:10.1038/sj.emboj.7600424. PMC 526458. PMID 15496986.
• Chiapperino D, Cai M, Sayer JM, et al. (2006). "Error-prone translesion synthesis by human DNA polymerase eta on DNA-containing deoxyadenosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene". J. Biol. Chem. 280 (48): 39684–92. doi:10.1074/jbc.M508008200. PMID 16188888.
• Zan H, Shima N, Xu Z, et al. (2005). "The translesion DNA polymerase θ plays a dominant role in immunoglobulin gene somatic hypermutation". EMBO J. 24 (21): 3757–69. doi:10.1038/sj.emboj.7600833. PMC 1276717. PMID 16222339.
• Cruet-Hennequart S, Coyne S, Glynn MT, et al. (2006). "UV-induced RPA phosphorylation is increased in the absence of DNA polymerase eta and requires DNA-PK". DNA Repair (Amst.). 5 (4): 491–504. doi:10.1016/j.dnarep.2006.01.008. PMID 16520097.
• Chen YW, Cleaver JE, Hanaoka F, et al. (2006). "A novel role of DNA polymerase eta in modulating cellular sensitivity to chemotherapeutic agents". Mol. Cancer Res. 4 (4): 257–65. doi:10.1158/1541-7786.MCR-05-0118. PMID 16603639.
• Yuasa MS, Masutani C, Hirano A, et al. (2006). "A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest". Genes Cells. 11 (7): 731–44. doi:10.1111/j.1365-2443.2006.00974.x. PMID 16824193.
• Choi JY, Stover JS, Angel KC, et al. (2006). "Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site". J. Biol. Chem. 281 (35): 25297–306. doi:10.1074/jbc.M605699200. PMID 16835218.
• Kino K, Ito N, Sugasawa K, et al. (2007). "Translesion synthesis by human DNA polymerase eta across oxidative products of guanine". Nucleic Acids Symp Ser (Oxf). 48 (1): 171–2. doi:10.1093/nass/48.1.171. PMID 17150533.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.