Protein FAM43A is a protein that is encoded in humans by the FAM43A gene. The acronym means "family with sequence similarity 43, member A".[1] The specific function of FAM43A is currently unknown, and the gene has only been characterized in cDNA assays.[2]
Characteristics
FAM43A is located on chromosome 3 at location 3q29.[1] It encodes a 3182 base pair mRNA which possesses one Pleckstrin homology-like domain. The mRNA translates into LOC131583, a hydrophilic protein 423 amino acids long.[1][3] The protein has been predicted to localize in the nucleus, and possesses a cut signal peptide at amino acid 21.[4]
Conservation
The FAM43A gene is conserved through a broad range of vertebrates.[5] Conservation is extremely high among primates, remaining significant among species as distant as zebrafish.[6]
References
- ↑ 1.0 1.1 1.2 NCBI entry on FAM43A
- ↑ Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (Nov 2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc Natl Acad Sci U S A. 101 (44): 15724–15729. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
- ↑ SDSC Biology WorkBench
- ↑ ExPASy Proteomics tools
- ↑ NCBI blast
- ↑ ECR browser