Carbohydrate (chondroitin 4) sulfotransferase 13 is a protein that is encoded in humans by the CHST13 gene.
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Function
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to the C4 hydroxyl of beta-1,4-linked N-acetylgalactosamine (GalNAc) flanked by glucuronic acid residue in chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. [provided by RefSeq, Aug 2011]. ##Evidence-Data-START## Transcript exon combination :: AY120869.1, BC103895.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025087, ERS025091 [ECO:0000348] ##Evidence-Data-END##
Kang, H. G.; Evers, M. R.; Xia, G; Baenziger, J. U.; Schachner, M (2002). "Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases". Journal of Biological Chemistry. 277 (38): 34766–72. doi:10.1074/jbc.M204907200. PMID12080076.
Valente, B; Campos, P. A.; Do Rosário, V. E.; Silveira, H (2010). "Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria". Transactions of the Royal Society of Tropical Medicine and Hygiene. 104 (10): 687–9. doi:10.1016/j.trstmh.2010.05.005. PMID20580388.
Hiraoka, N; Nakagawa, H; Ong, E; Akama, T. O.; Fukuda, M. N.; Fukuda, M (2000). "Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family". Journal of Biological Chemistry. 275 (26): 20188–96. doi:10.1074/jbc.M002443200. PMID10781601.
