Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene .
[1]
Unc93A is an Major facilitator superfamily (MFS), and a putative Solute carrier in humans.[2] [3] atypical SLCs that was recently listed.[2]
UNC93A is closely related to Unc93B1 and MFSD11 .[4] [5]
UNC93A is affected by amino acid deprivation in cell cortex cultures[3] [4] in vivo samples.[4]
It is expressed in neurons, with staining close to the plasma membrane.[4]
Read also [6] [7]
References
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"Entrez Gene: Unc-93 homolog A (C. elegans)" . Retrieved 2014-04-23 .
↑ 2.0 2.1 Perland, Emelie; Fredriksson, Robert (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences . 38 (3): 305–315. doi :10.1016/j.tips.2016.11.008 . ISSN 1873-3735 . PMID 27939446 . ↑ 3.0 3.1 Perland, Emelie; Bagchi, Sonchita; Klaesson, Axel; Fredriksson, Robert (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression" . Open Biology . 7 (9). doi :10.1098/rsob.170142 . ISSN 2046-2441 . PMC 5627054 PMID 28878041 . ↑ 4.0 4.1 4.2 4.3 Ceder, Mikaela M.; Lekholm, Emilia; Hellsten, Sofie V.; Perland, Emelie; Fredriksson, Robert (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice" . Frontiers in Molecular Neuroscience . 10 . doi :10.3389/fnmol.2017.00351 . ISSN 1662-5099 . ↑ Perland, Emelie; Lekholm, Emilia; Eriksson, Mikaela M.; Bagchi, Sonchita; Arapi, Vasiliki; Fredriksson, Robert (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis" . PLoS ONE . 11 (6): e0156912. doi :10.1371/journal.pone.0156912 . ISSN 1932-6203 . PMC 4896477 PMID 27272503 . ↑ Levin, J. Z.; Horvitz, H. R. (April 1992). "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction" . The Journal of Cell Biology . 117 (1): 143–155. ISSN 0021-9525 . PMC 2289394 PMID 1313436 . ↑ de la Cruz, Ignacio Perez; Levin, Joshua Z.; Cummins, Claudia; Anderson, Philip; Horvitz, H. Robert (2003-10-08). "sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans". The Journal of Neuroscience . 23 (27): 9133–9145. ISSN 1529-2401 . PMID 14534247 .
Further reading
