Shroom family member 2

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
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Wikidata
View/Edit Human

Shroom family member 2 is a protein that in humans is encoded by the SHROOM2 gene.

Function

This gene represents the human homolog of Xenopus laevis apical protein (APX) gene, which is implicated in amiloride-sensitive sodium channel activity. It is expressed in endothelial cells and facilitates the formation of a contractile network within endothelial cells. Depletion of this gene results in an increase in endothelial sprouting, migration, and angiogenesis. This gene is highly expressed in the retina, and is a strong candidate for ocular albinism type 1 syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016].

Further reading

• Farber MJ, Rizaldy R, Hildebrand JD (2011). "Shroom2 regulates contractility to control endothelial morphogenesis". Mol. Biol. Cell. 22 (6): 795–805. doi:10.1091/mbc.E10-06-0505. PMC 3057704. PMID 21248203.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.