Pleomorphic adenoma classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Pleomorphic adenoma can be classified into 4 subgroups on the basis of histological appearance and stromal content. Subgroup 1(30-50%) of stromal content, subgroup 2(80%), subgroup 3(20-30%), subgroup 4(6%).
Classification
- Pleomorphic adenoma can be classified based on the stromal content of the tumor into the following subgroups.[1]
- Subgroup 1 is the classical pleomorphic adenoma with a stroma content of 30-50%
- subgroup 2 has a stroma content of 80%
- subgroup 3 has a poor stroma content of 20-30% or less and an epithelial differentiation similar to subgroup 1
- subgroup 4 has also a poor stroma content (6%) with a relatively monomorphic epithelial structure.
- Depending upon which component predominates pleomorphic adenoma can also be classified into:[2]
- Cellular(either epithelial or myoepithelial cell rich)
- Stroma-rich
- Mixed type or classic
References
- ↑ Seifert G, Langrock I, Donath K (December 1976). "[A pathological classification of pleomorphic adenoma of the salivary glands (author's transl)]". HNO (in German). 24 (12): 415–26. PMID 1002574.
- ↑ Zhan, Kevin Y.; Khaja, Sobia F.; Flack, Allen B.; Day, Terry A. (2016). "Benign Parotid Tumors". Otolaryngologic Clinics of North America. 49 (2): 327–342. doi:10.1016/j.otc.2015.10.005. ISSN 0030-6665.