Chronic neutrophilic leukemia laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2]
Overview
Laboratory findings consistent with the diagnosis of chronic neutrophilic leukemia (CNL) include chronic neutrophilia. Mild anemia, thrombocytopenia, elevation of lactate dehydrogenase and vitamin B12.
Laboratory Findings
A chronic elevated concentration of blood mature neutrophils is diagnostic for CNL.[1]
Some patients with CNL may have:[2][1][3]
Blood tests:
- Peripheral blood White blood cells (WBC) ≥25 ×109/L
- Segmented neutrophils plus band forms ≥80% of WBC
- Myeloblasts rarely observed
- Monocyte count <1 ×109/L
- Mild anemia
- Thrombocytopenia
Bone marrow test:
- Hypercellularity of bone marrow.
- Neutrophil granulocytes increased in percentage and number
- Normal neutrophil maturation
- Myeloblasts <5% of nucleated cells
Blood chemistry tests:
- Elevation of lactate dehydrogenase (LDH).
Blood vitamin analysis:
- Elevation of vitamin B12
Genetic tests:
- cytogenetic abnormalities which may seen:
- Trisomy 8
- Trisomy 21
- Deletion 11q
- Deletion 20q6
- Deletion Y
- Trisomy 7
- Trisomy 9
- Detection of JAK2V617F
References
- ↑ 1.0 1.1 Elliott, M A; Hanson, C A; Dewald, G W; Smoley, S A; Lasho, T L; Tefferi, A (2004). "WHO-defined chronic neutrophilic leukemia: a long-term analysis of 12 cases and a critical review of the literature". Leukemia. 19 (2): 313–317. doi:10.1038/sj.leu.2403562. ISSN 0887-6924.
- ↑ Hasle, Henrik; Olesen, Gitte; Kerndrup, GITTE; Philip, Preben; Jacobsen, Niels (1996). "Chronic neutrophil leukaemia in adolescence and young adulthood". British Journal of Haematology. 94 (4): 628–630. doi:10.1046/j.1365-2141.1996.7082329.x. ISSN 0007-1048.
- ↑ Elliott, Michelle A. (2006). "Chronic neutrophilic leukemia and chronic myelomonocytic leukemia: WHO defined". Best Practice & Research Clinical Haematology. 19 (3): 571–593. doi:10.1016/j.beha.2005.07.012. ISSN 1521-6926.