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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: , Gertrude Djouka, M.D.[2]

Differential diagnosis of neck masses==

Differential diagnosis of neck masses include:

Category	Diseases		Benign or Malignant	Clinical manifestation								Paraclinical findings			Gold standard diagnosis	Associated findings
				Demography	History	Symptoms		Signs				Lab findings	Histopathology	Imaging
						Pain	Dysphagia	Mass exam	Skin changes	LAP	Others
Congenital	Branchial cleft cyst		Benign
	Thyroglossal duct cyst
	Hemangioma
	Vascular malformations
	Lymphatic malformations
	Laryngocele
	Ranula
	Teratoma
	Dermoid cyst
	Thymic cyst
Category	Diseases		Benign or Malignant	Demography	History	Pain	Dysphagia	Mass exam	Skin changes	LAP	Others	Lab findings	Histopathology	Imaging	Gold standard diagnosis	Associated findings
Inflammatory	Acute sialadenitis
	Chronic sialadenitis
	Reactive viral lymphadenopathy	CMV
		EBV
		HIV
		Viral URI
	Bacterial lymphadenopathy	Tularemia
		Brucellosis
		Cat-scratch disease	Benign	More common in the Southern of U.S among children and young adults.	Cat exposure Fever Fatigue headache	+	-	Tender cervical nodes	Vesicular, Erythema, Papule at site of inoculation	+		ESR Serology: + antibody to Bartonella Henselae	Satellite micro-abscess with granuloma	-	-	Bacillary Angiomatosis Bacillary Peliosis
		Actinomycosis	Benign	No predilection in race, age Male to female ratio : 1.5 to 3:1	History of dental procedure or trauma Poor oral hygiene Swelling mandible	-	-	Tender at the beginning , Painless Fluctuant Non-tender at late stage	Reddish Bluish	-		ESR CRP Gram stains: Gram + filamentous rods	Sulfur granules Filamentous organism	-	Histological examination Bacterial culture of the abcess	mandible osteomyelitis
		Mycobacterial infections	Benign	More common in adults and children in endemic continent such as African	Recent travel to endemic regions Exposure to TB patients	-	-	Matted cervical nodes Firm Non-tender	Indurated	+		PPD: + Sputum smear: presence of acid fast bacilli	Chronic necrotizing caseating calcified granuloma	Neck Ultrasound: Multiple lymph nodes Fusion tendency Internal echoes	Culture for mycobacteria	-
		Staphylococcal or streptococcal infection	Benign	More common in children		+	+	+		+		Gram stain: gram (+) cocci in clusters for Staph Gram (+) cocci in chains for strep Blood Culture: +	Follicular hyperplasia Infiltration of polymorphonuclear cells			Acute rheumatic fever Post-streptoccocal glomerulonephritis
	Parasitic lymphadenopathy	Toxoplasma gondii	Benign	6 years and older adults are more affected in U.S. Seen in Hot climates	Cats or birds feces exposure Drinking unpasteurized milk Undercooked food Organ transplant recipients	+	-	Bilateral Non-tender Symmetrical Non-fluctuant	-	+		Serology : + IgG and IgM antibodies	Follicular hyperplasia	MRI: Multiple rings enhanced lesions	Serology Immunofluorescence MRI CT scan
	Sarcoidosis		Benign	More common in African American women aged 20 - 40 years.	Family history of sarcodosis, Fatigue, swelling and pain in the joints,	-	-	Bilateral tender LAD Swollen, non-tender parotid glands	Erythema nodosum, Lupus pernios	+		ESR ACE	Non-necrotizing epithelioid granuloma	CXR: B/L hilar adenopathy MRI: B/L multiples enlarged cervical lymph nodes	Biopsy	Heerfordt's syndrome: uveitis, facial nerve paralysis, parotitis
	Amyloidosis		Benign	Men are affected women. Mean age: 55-60 years old						+					Biopsy
	Sjögren syndrome		Benign	Female to male ratio: 9 to 1 May happen at any age Mean age: 40-50	History of RA, SLE, and non-hodgkin B-cell lymphoma. Dry mouth, dry eyes.	-	+	Firm, B/L enlarged parotid glands	Itchy Rashes Dry	+		ESR Anti-SSA/Ro Anti-SSB/La Cytopenia	Hyperactivity of B cells and lymphocytes which lead to infiltration of the exocrine glands.		Biopsy
	Castleman disease (angiofollicular lymphoproliferative disease)		Benign	Mean age: 30-40 years											Biopsy
	Kikuchi disease (histiocytic necrotizing lymphadenitis)		Benign	High prevalence in Japan More common in young adults <30 years old	Fever Flu-like prodrome	+	-	Tender cervical node	rashes	+		ESR Abnormal liver enzymes leucopenia	Irregular paracortical areas of coagulative necrosis with abundant karyorrhectic debris	-	Biopsy	Hashimoto thyroiditis
	Kimura disease		Benign	More common in Asian males.	History of painless cervical lump	-	-	Large Non-tender cervical node	Ictching	+		Increase eosinophils	Conserved lymph node structure Eosinophilic infiltration High postcapillary venules	-	Biospsy	Nephrotic syndrom Hypercoaguble state
	Rosai-Dorfman disease		Benign	More common in children	Fever	-	-	Non-tender enlarged cervical lymph nodes	Erythema	+		ESR Polyclonal hypergammaglobulinemia	-	-	-	-
	Kawasaki disease		Benign	More common in children younger than 5 years old. Highest incidence in Japan. Most leading cause of acquired heart disease in U.S.	High fever B/L conjunctivitis Rash Swelling of hands and feet Inflammation of lips Strawberry tongue	-	-	Large, single palpable cervical node	Rashes Desquamation of skin	+		ESR CRP	Inflammation of medium sized arteries and organs.	Echocardiography: Coronary artery dilation Coronary artery aneurysm	Clinical findings
Category	Diseases		Benign or Malignant	Demography	History	Pain	Dysphagia	Mass exam	Skin changes	LAP	Others	Lab findings	Histopathology	Imaging	Gold standard diagnosis	Associated findings
Neoplasm	Primary thyroid tumor
	Salivary gland neoplasm	Pleomorphic adenoma	Benign	More common in Females Incidence increase with age. Incidence : 2-3.5 cases per 100,000 population	History of swelling, Dysphagia Horseness	-	+	Palpable mass of deep lobe of parotid gland Firm Mobile	-	-		-	Proliferation of epithelial cells and stromal matrix in the ducts.	MRI: Homogenous on T1 Abundant myxochondroid stroma on T2	Biopsy
		Warthin's tumour	Benign	Male to Female ratio : 4:1 More common in people aged 60 to 70 years old.	History of swollen salivary gland Jaw pain Tinnitus	-	+	Non tender Mobile Firm Solitary	-	-		-	Papillae Fibrous capsule Cystic spaces	Neck CT: Cystic lesion posteriorly within the parotid gland. MRI: B/L lesions Heterogeneous	Biopsy
		Lymphoepithelioma	+
		Oncocytoma
		Monomorphic adenoma
		Mucoepidermoid carcinoma
		Adenoid cystic carcinoma
		Adenocarcinoma
		Salivary duct carcinoma
		Squamous cell carcinoma
	Parathyroid tumors
	Carotid body tumors
	Paraganglioma
	Schwannoma
	Lymphoma
	Liposarcoma
	Lipoma
	Glomus vagale, glomus jugulare tumors
	Metastatic head and neck carcinoma
Other	Hematoma
	Arteriovenous fistula
	Goiter
Category	Diseases		Benign	Demography	History	Pain	Dysphagia	Mass exam	Skin changes	LAP	Others	Lab findings	Histopathology	Imaging	Gold standard diagnosis	Associated findings