Waldenström's macroglobulinemia bone marrow aspiration and biopsy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Roukoz A. Karam, M.D.[2]
Overview
A bone marrow aspiration is essential in the diagnosis of Waldenström macroglobulinemia.
Bone Marrow Aspirate
A bone marrow aspirate is essential in the diagnosis of Waldenström macroglobulinemia.
Findings suggestive of Waldenström macroglobulinemia include:[1]
- A hypercellular bone marrow aspirate.
- Lymphoplasmacytic infiltrate with characteristic immunophenotype.
Bone Marrow Biopsy
A bone marrow biopsy may be helpful in the diagnosis of Waldenström macroglobulinemia. [1]
Findings on the biopsy suggestive of Waldenström macroglobulinemia include:[1]
- Hypercellular and infiltrated with lymphoid and plasmacytoid cells.
- Dutcher bodies (PAS positive intra-nuclear vacuoles containing IgM monoclonal protein)
- Characteristic feature of Waldenström macroglobulinemia
Three patterns of marrow involvement are described, as follows:
- Lymphoplasmacytoid cells (lymphoplasmacytic and small lymphocytes) in a nodular pattern
- Lymphoplasmacytic cells (small lymphocytes, mature plasma cells, mast cells) in an interstitial/nodular pattern
- A polymorphous infiltrate (small lymphocytes, plasma cells, plasmacytoid cells, immunoblasts with mitotic figures)
References
- ↑ 1.0 1.1 1.2 Leleu X, Roccaro AM, Moreau AS, Dupire S, Robu D, Gay J; et al. (2008). "Waldenstrom macroglobulinemia". Cancer Lett. 270 (1): 95–107. doi:10.1016/j.canlet.2008.04.040. PMC 3133633. PMID 18555588.