Cowden syndrome natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

Overview

Cowden syndrome follows an autosomal dominant pattern of inheritance. If left untreated, patients with cowden syndrome may prone to develop manu cancers.Common complications of cowden syndrome include breast, colon cancer and endometrial cancer. Prognosis is generally ranges from excellent to poor.

The symptoms of cowden syndrome usually varies and develops in ranging from birth to age 46 years.
If left untreated, patients with cowden syndrome may prone to develop many cancers.

Prognosis is generally ranges from excellent to poor, and the mortality rate of patients with cowden syndrome is based on malignant tumors associated with it.
The presence of benign tumours is associated with a particularly poor prognosis among patients with cowden syndrome.

↑ FitzGerald MG, Marsh DJ, Wahrer D, Bell D, Caron S, Shannon KE, Ishioka C, Isselbacher KJ, Garber JE, Eng C, Haber DA (August 1998). "Germline mutations in PTEN are an infrequent cause of genetic predisposition to breast cancer". Oncogene. 17 (6): 727–31. doi:10.1038/sj.onc.1201984. PMID 9715274.