Ovarian germ cell tumor medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Overview

Among ovarian germ cell tumors, only dysgerminoma is radiosensitive. Raditherapy is not anymore the first opttion of tratment for dysgerminoma considering its association with ovarian failure development.

Not all the ovarian germ cell tumors are radiosensitive.^[1]
Dysgerminoma is a radiosensitive tumor.
Radiotherapy is not the first option for treating dysgerminoma and it reserved for patients for whom chemotherapy is contraindicated for whatever reason.
Whole abdomina radiotherapy is used for the treatment of dysgerminoma, however, it may be associated with ovarian failure.^[2]

↑ Chen VW, Ruiz B, Killeen JL, Coté TR, Wu XC, Correa CN (May 2003). "Pathology and classification of ovarian tumors". Cancer. 97 (10 Suppl): 2631–42. doi:10.1002/cncr.11345. PMID 12733128.
↑ Mitchell, Michele Follen; Gershenson, David M.; Soeters, Robbert-Paul; Eifel, Patricia J.; Delclos, Luis; Wharton, J. Taylor (1991). "Long-term effects of radiation therapy on patients with ovarian dysgerminoma". Cancer. 67 (4): 1084–1090. doi:10.1002/1097-0142(19910215)67:4<1084::AID-CNCR2820670436>3.0.CO;2-E. ISSN 0008-543X.