Retinoblastoma historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Retinoblastoma was first described in 1809 by James Wardrop.

In 1657, Dr. Petrus Pawius, an anatomist from Amesterdam, described a tumor resembling retinoblastoma for the first time.^[1]
In 1809, Dr. James Wardrop, Scottish surgeon and ophthalmologist, first described the retinoblastoma tumor.
In 1971, Dr. Knudson proposed the two-hit hypothesis which give the light to the pathogenesis of the familial and sporadic form of the tumor.^[2]
In 1899, Flexner and Wintersteiner were the first to discover the association between tumor rosettes and photoreceptors of the adult retina.
In 1920s Verhoeff claimed that the tumor arose from embryonic retinal cells and hence proposed the name "retinoblastoma".

↑ Albert, Daniel M. (1987). "Historic Review of Retinoblastoma". Ophthalmology. 94 (6): 654–662. doi:10.1016/S0161-6420(87)33407-4. ISSN 0161-6420.
↑ Knudson AG (April 1971). "Mutation and cancer: statistical study of retinoblastoma". Proc. Natl. Acad. Sci. U.S.A. 68 (4): 820–3. PMC 389051. PMID 5279523.