Renal oncocytoma epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2] Shanshan Cen, M.D. [3]
Age
- The incidence of renal oncocytoma increases with age; the median age at diagnosis is 55 years.
Oncocytomas make up 3% to 7% of all renal epithelial tumors.[1] They are most commonly seen in adults older than 50 years, are more common in males, and have a peak frequency in the seventh decade of life. However, these tumors rarely occur in the pediatric population.[1]
This lesion is commonly seen in patients with Birt-Hogg-Dube syndrome. These patients develop a mean of 5.3 renal tumors in their lifetime. These lesions consist mostly of chromophobe renal carcinoma and oncocytomas
Overview
Epidemiology and Demographics
Incidence
Age
- Patients of all age groups may develop renal oncocytoma.
- The incidence of renal oncocytoma increases with age; the median age at diagnosis is 55 years.
Gender
- Males are more commonly affected by renal oncocytoma than females. The male to female ratio is approximately 2 to 1.[3]
Later, Klein andValensi2 identified another 13 cases as a distinctive clinical pathological entity, which they introduced in the English literature as “proximal tubular adenoma with oncocytic
features”. This specific prodrome, by convention now called “renal oncocytoma”, comprises approximately 5% of all neoplasms of renal cells in surgical series. The ages of patients with typical renal oncocytoma have varied considerably. Patients have ranged in age from 10 years to 94 years.3–6 The peak incidence of detection is in the seventh decade of life. This finding suggests that renal oncocytomas occur in a relatively older age group than in those patients with typical renal cell carcinoma (RCC), for whom the median age in large series is always approximately 55 years. However, taking into account that renal oncocytoma grows very slowly, it might start developing at an earlier age, around 30–50 years. For the cases of renal oncocytoma with reported sex, men are affected nearly twice as often as women
References
- ↑ Rosenkrantz, Andrew B.; Hindman, Nicole; Fitzgerald, Erin F.; Niver, Benjamin E.; Melamed, Jonathan; Babb, James S. (2010). "MRI Features of Renal Oncocytoma and Chromophobe Renal Cell Carcinoma". American Journal of Roentgenology. 195 (6): W421–W427. doi:10.2214/AJR.10.4718. ISSN 0361-803X.
- ↑ B. Perez-Ordonez, G. Hamed, S. Campbell, R. A. Erlandson, P. Russo, P. B. Gaudin & V. E. Reuter (1997). "Renal oncocytoma: a clinicopathologic study of 70 cases". The American journal of surgical pathology. 21 (8): 871–883. PMID 9255250. Unknown parameter
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ignored (help) - ↑ Yusenko, Maria V (2010). "Molecular pathology of renal oncocytoma: A review". International Journal of Urology. 17 (7): 602–612. doi:10.1111/j.1442-2042.2010.02574.x. ISSN 0919-8172.