Retinoblastoma MRI

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [3]

Overview

On head and neck MRI, retinoblastoma is characterized by isointense to hypointense mass on T1-weighted MRI and hyperintense mass on T2-weighted MRI.^[1]

MRI

MRI imaging study of retinoblastoma first introduced in 1980.^[2]
This method is used as an extra diagnostic method to CT scan in suspected retinoblastoma cases especially in those whose CT scan imaging is doubtful for the presence of extra-ocular extension.^[3]
MRI diagnostic value in the diagnosis of advanced retinoblastoma is greater than CT scan.^[4]

MRI findings diagnostic of retinoblastoma are:

On T1 image:Hyperintense mass compared to vitrous body
On T2 image:Hypointense mass compared to vitrous body
It should be mentined that MRI is accurate for tumor staging and evaluation of metastatic risk factors.^[5]

MRI is the modality of choice for pre-treatment staging on retinoblastoma.

The MRI features of retinoblastoma include:^[1]


MRI component	Features

T1	Intermediate signal intensity, hyperintense c.f. vitreous
T2	Hypointense c.f. vitreous
T1 contrast with gadolinium	The mass usually enhances relatively homogeneously when small Larger tumors often have areas of necrosis, rendering it heterogeneous Linear enhancement of the choroid beyond the margins of the tumour should raise the possibility of choroidal involvement, although inflammation may lead to similar appearance Enhancement of the anterior chamber need not represent tumour involvement, with hyperaemia, uveitis and iris neovascularisation all leading to asymmetric enhancement Careful assessment of the optic disc and optic nerve should be carried out to assess for involvement Extra-ocular extension through the sclera will be visible as interruption of the otherwise hypointense non-enhancing sclera by enhancing tumour
Diffusion Weighted Imaging	The tumour shows restricted diffusion on DWI at high b values. It exhibits low ADC values in contrast to the high intensity of the vitreous in the ADC maps ADC map can be used to differentiate viable and necrotic tumour DWI is valuable in evaluating the response to eye-preservation treatment

References

↑ ^1.0 ^1.1 Retinoblastoma. Radiopedia(2015) http://radiopaedia.org/articles/retinoblastoma Accessed on October 10, 2015
↑ Schueler, A O (2003). "High resolution magnetic resonance imaging of retinoblastoma". British Journal of Ophthalmology. 87 (3): 330–335. doi:10.1136/bjo.87.3.330. ISSN 0007-1161.
↑ Meel R, Radhakrishnan V, Bakhshi S (April 2012). "Current therapy and recent advances in the management of retinoblastoma". Indian J Med Paediatr Oncol. 33 (2): 80–8. doi:10.4103/0971-5851.99731. PMC 3439795. PMID 22988349.
↑ de Jong, Marcus C.; de Graaf, Pim; Noij, Daniel P.; Göricke, Sophia; Maeder, Philippe; Galluzzi, Paolo; Brisse, Hervé J.; Moll, Annette C.; Castelijns, Jonas A. (2014). "Diagnostic Performance of Magnetic Resonance Imaging and Computed Tomography for Advanced Retinoblastoma". Ophthalmology. 121 (5): 1109–1118. doi:10.1016/j.ophtha.2013.11.021. ISSN 0161-6420.
↑ de Graaf, Pim; Barkhof, Frederik; Moll, Annette C.; Imhof, Saskia M.; Knol, Dirk L.; van der Valk, Paul; Castelijns, Jonas A. (2005). "Retinoblastoma: MR Imaging Parameters in Detection of Tumor Extent". Radiology. 235 (1): 197–207. doi:10.1148/radiol.2351031301. ISSN 0033-8419.
↑ ^6.0 ^6.1 ^6.2 Image courtesy of Radswiki Radiopaedia (original file [1]).[http://radiopaedia.org/licence Creative Commons BY-SA-NC

Template:WikiDoc Sources

[radio-1] 1.0 ^1.1 Retinoblastoma. Radiopedia(2015) http://radiopaedia.org/articles/retinoblastoma Accessed on October 10, 2015

[Schueler2003-2] Schueler, A O (2003). "High resolution magnetic resonance imaging of retinoblastoma". British Journal of Ophthalmology. 87 (3): 330–335. doi:10.1136/bjo.87.3.330. ISSN 0007-1161.

[pmid22988349-3] Meel R, Radhakrishnan V, Bakhshi S (April 2012). "Current therapy and recent advances in the management of retinoblastoma". Indian J Med Paediatr Oncol. 33 (2): 80–8. doi:10.4103/0971-5851.99731. PMC 3439795. PMID 22988349.

[de_Jongde_Graaf2014-4] Jong, Marcus C.; de Graaf, Pim; Noij, Daniel P.; Göricke, Sophia; Maeder, Philippe; Galluzzi, Paolo; Brisse, Hervé J.; Moll, Annette C.; Castelijns, Jonas A. (2014). "Diagnostic Performance of Magnetic Resonance Imaging and Computed Tomography for Advanced Retinoblastoma". Ophthalmology. 121 (5): 1109–1118. doi:10.1016/j.ophtha.2013.11.021. ISSN 0161-6420.

[de_GraafBarkhof2005-5] Graaf, Pim; Barkhof, Frederik; Moll, Annette C.; Imhof, Saskia M.; Knol, Dirk L.; van der Valk, Paul; Castelijns, Jonas A. (2005). "Retinoblastoma: MR Imaging Parameters in Detection of Tumor Extent". Radiology. 235 (1): 197–207. doi:10.1148/radiol.2351031301. ISSN 0033-8419.

[radio1-6] 6.0 ^6.1 ^6.2 Image courtesy of Radswiki Radiopaedia (original file [1]).[http://radiopaedia.org/licence Creative Commons BY-SA-NC

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Retinoblastoma MRI

Overview

MRI

References

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