Mast cell tumor historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

In 1869, Dr. Nettleship and Tay were the first ever to discuss the mast cell activation and it was in a case of urticaria pigmentosa.^[1]
In 1936, Dr. Sézary and other french scientists reported the first case of systemic mastocytosis or mast cell tumor.
Dr. Sezary describes the systemic mastocytosis as aberrant mast cell proliferation which is characterized by release of immense vasoactive amines.^[2]