Ameloblastoma natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]:Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2], Simrat Sarai, M.D. [3]
Overview
Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
Natural History, Complications, and Prognosis
Natural History
- In several cases, the patients with ameloblastoma are asymptomatic.[1][2][3]
- Ameloblastoma most commonly diagnosed as an accidental finding on orthopantomography.
- The most common symptoms in patients with ameloblastoma are as following:
- Facial swelling
- Malocclusion
- Loosening of teeth
- ILL-fitting dentures
- Periodontal diseases
- Oroantral fistulas and
- Nasal airway obstruction
- Ameloblastoma is regarded as a true neoplasm of enamel.
- Ameloblastoma described as unicentric, nonfunctional, intermittent in growth.
- Ameloblastoma is the second most common odontogenic neoplasm.
- Ameloblastoma histologically classified as six subtypes:
- Follicular subtype
- Plexiform subtype
- Acanthomatous subtype
- Granular subtype
- Desmoplastic subtype and
- Basilar subtype.
- Ameloblastoma most commonly affects mandible more than maxilla.
- Ameloblastomal progress as a slow growing, painless expansion of jaw
Complications
- Complications of ameloblastoma include the following:[4][5]
- The recurrence rate of these tumors is 25-30%.
Prognosis
- The prognosis of ameloblastoma was determined mainly by the method of surgical treatment, which means that patients receiving a radical treatment had a better prognosis than those who received a radical one. [6][7]
- In more than 50% patients receiving the conservative treatment had good prognosis without any recurrence.
- Ameloblastoma which has a well-defined edge with sclerosis is thought to grow slowly, and the normal bone has a strong reaction to form the sclerosis edge, and the prognosis is good.
- Ameloblastomawith the ill-defined radiographic boundary, the tumor has the highest proliferative ability and poorest prognosis.
- Radical surgery should be used for the multicystic ameloblastoma to prevent the recurrence.
- The follicular ameloblastoma were thought to have a higher recurrence rate than unicystic or plexiform.[8]
References
- ↑ Gümgüm S, Hoşgören B (2005). "Clinical and radiologic behaviour of ameloblastoma in 4 cases". J Can Dent Assoc. 71 (7): 481–4. PMID 16026635.
- ↑ Morgan, Peter R. (2011). "Odontogenic tumors: a review". Periodontology 2000. 57 (1): 160–76. doi:10.1111/j.1600-0757.2011.00393.x. ISSN 0906-6713.
- ↑ Ruslin, M; Hendra, FN; Vojdani, A; Hardjosantoso, D; Gazali, M; Tajrin, A; Wolff, J; Forouzanfar, T (2017). "The Epidemiology, treatment, and complication of ameloblastoma in East-Indonesia: 6 years retrospective study". Medicina Oral Patología Oral y Cirugia Bucal: 0–0. doi:10.4317/medoral.22185. ISSN 1698-6946.
- ↑ Ruslin, M; Hendra, FN; Vojdani, A; Hardjosantoso, D; Gazali, M; Tajrin, A; Wolff, J; Forouzanfar, T (2017). "The Epidemiology, treatment, and complication of ameloblastoma in East-Indonesia: 6 years retrospective study". Medicina Oral Patología Oral y Cirugia Bucal: 0–0. doi:10.4317/medoral.22185. ISSN 1698-6946.
- ↑ Mukhopadhyay S, Raha K, Mondal SC (July 2005). "Huge ameloblastoma of jaw-A case report". Indian J Otolaryngol Head Neck Surg. 57 (3): 247–8. doi:10.1007/BF03008023. PMC 3451340. PMID 23120181.
- ↑ Ruslin, M; Hendra, FN; Vojdani, A; Hardjosantoso, D; Gazali, M; Tajrin, A; Wolff, J; Forouzanfar, T (2017). "The Epidemiology, treatment, and complication of ameloblastoma in East-Indonesia: 6 years retrospective study". Medicina Oral Patología Oral y Cirugia Bucal: 0–0. doi:10.4317/medoral.22185. ISSN 1698-6946.
- ↑ Mukhopadhyay S, Raha K, Mondal SC (July 2005). "Huge ameloblastoma of jaw-A case report". Indian J Otolaryngol Head Neck Surg. 57 (3): 247–8. doi:10.1007/BF03008023. PMC 3451340. PMID 23120181.
- ↑ Li, Yi; Han, Bo; Li, Long-Jiang (2012). "Prognostic and proliferative evaluation of ameloblastoma based on radiographic boundary". International Journal of Oral Science. 4 (1): 30–33. doi:10.1038/ijos.2012.8. ISSN 1674-2818.