Morton's neuroma overview

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Overview

Historical Perspective

Pathophysiology

Causes

Differentiating Morton's Neuroma from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

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History and Symptoms

Physical Examination

Laboratory Findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]Faizan Sheraz, M.D. [3]

Overview

Morton's neuroma is a benign neuroma of the interdigital plantar nerve. It is characterised by numbness and pain, relieved by removing footwear. Although it is labeled a "neuroma", many sources do not consider it a true tumor, but rather a thickening of existing tissue.

Historical Perspective

The condition was first correctly described by a chiropodist named Durlacher.

Pathophysiology

Morton's neuroma is associated with symptomatic collapse of the transverse arch by perineural fibrosis around a plantar digital nerve of the foot due to chronic traction and increased pressure/compression on the interdigital nerve. It is located at the third intermetatarsal space most commonly (between third and fourth metatarsals), and sometimes second or fourth interspaces or bifurcation of the fourth plantar digital nerve. Gross pathological features of morton's neuroma include adherent fibrofatty tissue, small, firm, oval, yellowish-white, slowly growing, palpable nodule on skin (no discoloration of skin on the top of nodule) and </=2cm in size. Histopathological analysis is characterized by extensive fibrosis around and within the nerve, digital artery, thrombosis, epineural and endoneural arterial thickening/vascular hyalinization, and degenerated/demyelinated axons.

Causes

The exact cause is unknown.

Differentiating Morton's Neuroma from other diseases

Morton's neuroma must be differentiated from other causes of pain in the forefoot.

Epidemiology and Demographics

Morton neuroma is more common in women than in men.

Risk Factors

Risk factors for Morton's neuroma include abnormal positioning of toes, flat feet, forefoot problems, high foot arches, tight shoes and high heels.

Natural History, Complications and Prognosis

Morton's neuroma can make walking difficult. Nonsurgical treatment does not always improve symptoms.

History and Symptoms

Symptoms include: pain on weight bearing, frequently after only a short time; the pain is felt as a shooting pain affecting the contiguous halves of two toes. Burning, numbness and parasthesia may also be experienced.

Physical Examination

Direct pressure between the metatarsal heads will replicate the symptoms, as will compression of the forefoot between the finger and thumb so as to compress the transverse arch of the foot.

Laboratory Findings

Blood tests are done to check for inflammation-related conditions, including certain forms of arthritis.

X-Ray

A foot x-ray may be done to rule out bone pathologies.

Other Diagnostic tests

Nerve testing (electromyography) cannot definitely diagnose Morton's neuroma, but may be used to rule out conditions that cause similar symptoms.

Medical Therapy

Non-surgical treatment is instituted first.

Surgery

In some cases, surgery may be needed to remove the thickened tissue. This can help relieve pain and improve foot function. Numbness after surgery is permanent, but should not be painful.

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