Palmar plantar erythrodysesthesia history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mandana Chitsazan, M.D.
Overview
The majority of patients with [disease name] are asymptomatic.
OR
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
History and Symptoms
Common Symptoms
The most common symptoms of PPE include:
- A prodrome of dysesthesia, usually as a tingling sensation in the fingers, palms and/or soles, progressing to a burning pain in a few days
- A well-defined edema and symmetrical erythema, more prominently over the fat pads of the distal phalanges
- Skip areas may be seen
- Extension to the dorsal surfaces of the extremities, or over joint surfaces can occur [1]
- Periungual skin involvement is also possible
- The palms of the hands are usually more frequently and more severely affected than the soles of the feet, and may be only are affected.[1] [2]
Less Common Symptoms
Less common symptoms include: [3] [4]
- Sensory impairment
- paresthesia
- pruritus
- A bullous variant (a severe form of this entity) specifically occurs with cytarabine or methotrexate.[5][6]
Involvement of other parts of the body is rare, even though mild erythema or morbilliform lesions might occasionally be seen on the trunk, trunk, neck, chest, scalp and extremitirs. [1] [7]
References
- ↑ 1.0 1.1 1.2 Baack BR, Burgdorf WH (1991). "Chemotherapy-induced acral erythema". J Am Acad Dermatol. 24 (3): 457–61. PMID 2061446.
- ↑ Lassere Y, Hoff P (2004). "Management of hand-foot syndrome in patients treated with capecitabine (Xeloda)". Eur J Oncol Nurs. 8 Suppl 1: S31–40. doi:10.1016/j.ejon.2004.06.007. PMID 15341880.
- ↑ Hui YF, Cortes JE (2000). "Palmar-plantar erythrodysesthesia syndrome associated with liposomal daunorubicin". Pharmacotherapy. 20 (10): 1221–3. PMID 11034047.
- ↑ "www.oncologynurseadvisor.com".
- ↑ Hellier I, Bessis D, Sotto A, Margueritte G, Guilhou JJ (1996). "High-dose methotrexate-induced bullous variant of acral erythema". Arch Dermatol. 132 (5): 590–1. PMID 8624164.
- ↑ Waltzer JF, Flowers FP (1993). "Bullous variant of chemotherapy-induced acral erythema". Arch Dermatol. 129 (1): 43–5. PMID 8420487.
- ↑ Kroll SS, Koller CA, Kaled S, Dreizen S (1989). "Chemotherapy-induced acral erythema: desquamating lesions involving the hands and feet". Ann Plast Surg. 23 (3): 263–5. PMID 2528937.