Palmar plantar erythrodysesthesia medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Medical Therapy
- Dose reduction, lengthening the interval between drug administration, and ultimately drug withdrawal, if necessary, appear to be the most effective strategy.[1]
- This strategy does not seem to affect the effectiveness of capecitabine [7] [8][5] [9] , however, for other drug regimens this might affect efficacy.[10]
- Specific treatments include:
· Pyridoxine (vitamin B6)105-107 (fluorouracil27,30,40,108, liposome encapsulated doxorubicin25,50,95, doxorubicin, docetaxel, capecitabine109, etoposide53)
· Potent topical corticosteroids110 (liposome encapsulated doxorubicin95, docetaxel16, cisplatin48, fluorouracil105,111): the best results have been demonstrated when used in conjunction with cold compresses and emollients.
· Oral corticosteroids (cytarabine112, doxorubicin, fluorouracil111, liposome encapsulated doxorubicin113, bleomycin5, and methotrexate60,114, vinorelbine71); premedication?
· Topical 99% dimethyl-sulfoxide: 4 times daily for 14 days (liposome encapsulated doxorubicin115)
References
- ↑ Lassere Y, Hoff P (2004). "Management of hand-foot syndrome in patients treated with capecitabine (Xeloda)". Eur J Oncol Nurs. 8 Suppl 1: S31–40. doi:10.1016/j.ejon.2004.06.007. PMID 15341880.
- ↑ Abushullaih S, Saad ED, Munsell M, Hoff PM (2002). "Incidence and severity of hand-foot syndrome in colorectal cancer patients treated with capecitabine: a single-institution experience". Cancer Invest. 20 (1): 3–10. PMID 11853000.
- ↑ Hansen RM, Quebbeman EJ, Ritch PS, Frick J, Anderson T (1987). "Continuous 5-fluorouracil infusion and pulse methotrexate/leucovorin for colorectal adenocarcinoma. A report of excessive toxicity". Am J Clin Oncol. 10 (3): 216–8. PMID 3496002.
- ↑ Gordon KB, Tajuddin A, Guitart J, Kuzel TM, Eramo LR, VonRoenn J (1995). "Hand-foot syndrome associated with liposome-encapsulated doxorubicin therapy". Cancer. 75 (8): 2169–73. doi:10.1002/1097-0142(19950415)75:8<2169::aid-cncr2820750822>3.0.co;2-h. PMID 7697608.
- ↑ 5.0 5.1 Gerbrecht BM (2003). "Current Canadian experience with capecitabine: partnering with patients to optimize therapy". Cancer Nurs. 26 (2): 161–7. PMID 12660565.
- ↑ Nagore E, Insa A, Sanmartín O (2000). "Antineoplastic therapy-induced palmar plantar erythrodysesthesia ('hand-foot') syndrome. Incidence, recognition and management". Am J Clin Dermatol. 1 (4): 225–34. doi:10.2165/00128071-200001040-00004. PMID 11702367.
- ↑ Blum JL, Jones SE, Buzdar AU, LoRusso PM, Kuter I, Vogel C; et al. (1999). "Multicenter phase II study of capecitabine in paclitaxel-refractory metastatic breast cancer". J Clin Oncol. 17 (2): 485–93. doi:10.1200/JCO.1999.17.2.485. PMID 10080589.
- ↑ Cassidy J, Twelves C, Van Cutsem E, Hoff P, Bajetta E, Boyer M; et al. (2002). "First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin". Ann Oncol. 13 (4): 566–75. doi:10.1093/annonc/mdf089. PMID 12056707.
- ↑ O'Shaughnessy J, Miles D, Vukelja S, Moiseyenko V, Ayoub JP, Cervantes G; et al. (2002). "Superior survival with capecitabine plus docetaxel combination therapy in anthracycline-pretreated patients with advanced breast cancer: phase III trial results". J Clin Oncol. 20 (12): 2812–23. doi:10.1200/JCO.2002.09.002. PMID 12065558.
- ↑ Lokich JJ, Ahlgren JD, Gullo JJ, Philips JA, Fryer JG (1989). "A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program Study". J Clin Oncol. 7 (4): 425–32. doi:10.1200/JCO.1989.7.4.425. PMID 2926468.
- ↑ Zimmerman GC, Keeling JH, Burris HA, Cook G, Irvin R, Kuhn J; et al. (1995). "Acute cutaneous reactions to docetaxel, a new chemotherapeutic agent". Arch Dermatol. 131 (2): 202–6. PMID 7857119.
- ↑ Zimmerman GC, Keeling JH, Lowry M, Medina J, Von Hoff DD, Burris HA (1994). "Prevention of docetaxel-induced erythrodysesthesia with local hypothermia". J Natl Cancer Inst. 86 (7): 557–8. doi:10.1093/jnci/86.7.557. PMID 7907667.