Germ cell tumor classification

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Types Subtypes Signs and Symptoms Histopathology Lab finding Treatment Prognosis
Gonadal

Seminoma

Gross: pale gray to yellow nodules that are uniform or slightly lobulated and often bulge from the cut surface
  • Complete blood count and blood chemistry tests.[1]
  • Abnormal serum tumor marker levels (LDH, HCG).[1][2]
  • CT: Metastases to the para-aortic, inguinal, or iliac lymph nodes. Visceral metastasis may also be seen.
  • Pelvic MRI: may be diagnostic. multinodular tumors of uniform signal intensity
  • Hypo- to isointense on T2-weighted images and inhomogenous enhancement on contrast enhanced T1-weighted images.[3]
  • Other diagnostic studies for seminoma include biopsy, FDG-PET scan, and bone scan.[4]

Dysgerminoma

Germinoma

Extragonadal Embryonic

Teratoma

Extraembryonic

Coriocarcinoma

Yolk sac tumor

  1. 1.0 1.1 Diagnosis of testicular cancer. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/diagnosis/?region=on. Accessed on March 2, 2016
  2. Diagnosis of seminoma. Wikipedia 2016. https://en.wikipedia.org/wiki/Seminoma. Accessed on March 3, 2016
  3. Radiographic features of testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiopaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on March 7, 2016
  4. Microscopic pathology of seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016