Extranodal NK-T-cell lymphoma epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
Epidemiology and Demographics
Mortality rate
- NK cell lymphoma shows a poor prognosis because of rapid local progression and distant metastasis.[1]
Race
- Natural Killer (NK) cell lymphoma is a rare disease. NK/T cell lymphoma, nasal type (NKTCL) and aggressive NK-cell leukemia (ANKCL) have a higher incidence in Asia, Central, and South America.[2]
- Nk cell lymphoma is usually associated with Epstein-Barr virus infection.
Gender
- Extranodal NK/T-cell lymphoma shows male preponderance.[3]
Region
- NK T cell lymphoma, nasal type (NNKTL) consist 3-10% of non-Hodgkin lymphoma in Asia and South America and less than 1% in Western countries.
- It is estimated the incidence of NNKTL is higher in Asia by 10-folds.
Age
- The median age of onset is approximately 50 years and it is common in elderly.
- Extranodal NK/T-cell lymphoma is a rare disease in children and often it is associated with mosquito-bite hypersensetivity or other EBV-associated disease.[4]
References
- ↑ Harabuchi Y, Imai S, Wakashima J, Hirao M, Kataura A, Osato T; et al. (1996). "Nasal T-cell lymphoma causally associated with Epstein-Barr virus: clinicopathologic, phenotypic, and genotypic studies". Cancer. 77 (10): 2137–49. doi:10.1002/(SICI)1097-0142(19960515)77:10<2137::AID-CNCR27>3.0.CO;2-V. PMID 8640683.
- ↑ Harabuchi Y, Imai S, Wakashima J, Hirao M, Kataura A, Osato T; et al. (1996). "Nasal T-cell lymphoma causally associated with Epstein-Barr virus: clinicopathologic, phenotypic, and genotypic studies". Cancer. 77 (10): 2137–49. doi:10.1002/(SICI)1097-0142(19960515)77:10<2137::AID-CNCR27>3.0.CO;2-V. PMID 8640683.
- ↑ Al Shawabkeh MA, Al Sulaiti M, Al Sa'ey H, Ganesan S (2016). "Nasal Type Extranodal Natural Killer/T (NK/T) Cell Lymphoma Presenting as Periorbital Cellulitis: A Case Report". Am J Case Rep. 17: 934–938. doi:10.12659/ajcr.899922. PMC 5153321. PMID 27932776.
- ↑ Seon HS, Roh JH, Lee SH, Kang EK (2013). "A case of hypersensitivity to mosquito bites without peripheral natural killer cell lymphocytosis in a 6-year-old Korean boy". J Korean Med Sci. 28 (1): 164–6. doi:10.3346/jkms.2013.28.1.164. PMC 3546098. PMID 23341729.