Acinic cell carcinoma epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]
Overview
Acinic cell carcinoma can appear at any age however, it is common in children.
- Acinic cell carcinoma appears in all age groups, but presents at a younger median age (approximately 52 years) than most other salivary gland cancers.
- Women are more frequently diagnosed than men.
- Occurrences in children are quite common.
- According to the National Cancer Data Base Report on cancer of the head and neck in the United States, the parotid gland was the predominant site of origin (86.3%) for reported acinic cell carcinoma.
- Regional and distant metastasis, high grade, and large tumor size were all more common among patients older than 30.
- No ethnic or racial predilection showed an association with acinic cell carcinoma.
Epidemiology and Demographics
Incidence
Prevalence
- In western countries, salivary gland carcinomas account for 4000 out of 100000 of all head and neck carcinomas, and approximately 80% of those occurring in parotid gland.[1][2]
- one out of six parotid gland cancer is acinic cell carcinoma.
Case-fatality rate/Mortality rate
Age
- Disturbution of acinic cell carcinoma between age groups seems to be quiet even, with a median age of 52 years, but it occurs mostly at a younger age.[3]
- Children are rarely affected with salivary gland carcinoma, but if they are , it is most likely to be acinic cell carcinoma.[4]
Race
- Acinic cell carcinoma is predominantly seen in in whites (85000 out of 100000 cases) and less in African nations(8000 out of 100000 cases)[5]
Gender
- There is a higher incidence among female with the ratio ranging from 1.43:1 to 1.57:1.[6]
Region
Developed Countries
Developing Countries
References
- ↑ Vander Poorten, V.; Triantafyllou, A.; Thompson, L. D. R.; Bishop, J.; Hauben, E.; Hunt, J.; Skalova, A.; Stenman, G.; Takes, R. P.; Gnepp, D. R.; Hellquist, H.; Wenig, B.; Bell, D.; Rinaldo, A.; Ferlito, A. (2015). "Salivary acinic cell carcinoma: reappraisal and update". European Archives of Oto-Rhino-Laryngology. 273 (11): 3511–3531. doi:10.1007/s00405-015-3855-7. ISSN 0937-4477.
- ↑ Al-Mamgani, Abrahim; van Rooij, Peter; Verduijn, Gerda M.; Meeuwis, Cees A.; Levendag, Peter C. (2012). "Long-term Outcomes and Quality of Life of 186 Patients With Primary Parotid Carcinoma Treated With Surgery and Radiotherapy at the Daniel den Hoed Cancer Center". International Journal of Radiation Oncology*Biology*Physics. 84 (1): 189–195. doi:10.1016/j.ijrobp.2011.11.045. ISSN 0360-3016.
- ↑ Neskey, David M.; Klein, Jonah D.; Hicks, Stephanie; Garden, Adam S.; Bell, Diana M.; El-Naggar, Adel K.; Kies, Merrill S.; Weber, Randal S.; Kupferman, Michael E. (2013). "Prognostic Factors Associated With Decreased Survival in Patients With Acinic Cell Carcinoma". JAMA Otolaryngology–Head & Neck Surgery. 139 (11): 1195. doi:10.1001/jamaoto.2013.4728. ISSN 2168-6181.
- ↑ Khosravi, Mohammad Hossein; Bagherihagh, Ali; Saeedi, Masoumeh; Dabirmoghaddam, Payman; Kouhi, Ali; Amirzade-Iranaq, Mohammad Hosein (2017). "Salivary Gland Cancers: A Survey through History, Classifications and Managements". doi:10.5772/intechopen.70127.
- ↑ Gomez, Daniel R.; Katabi, Nora; Zhung, Joanne; Wolden, Suzanne L.; Zelefsky, Michael J.; Kraus, Dennis H.; Shah, Jatin P.; Wong, Richard J.; Ghossein, Ronald A.; Lee, Nancy Y. (2009). "Clinical and pathologic prognostic features in acinic cell carcinoma of the parotid gland". Cancer. 115 (10): 2128–2137. doi:10.1002/cncr.24259. ISSN 0008-543X.
- ↑ Hoffman HT, Karnell LH, Robinson RA, Pinkston JA, Menck HR (1999). "National Cancer Data Base report on cancer of the head and neck: acinic cell carcinoma". Head Neck. 21 (4): 297–309. PMID 10376748.