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Cutaneous cryptococcosis:
- Cryptococcus neoformans is an encapsulated yeast
- Occurs in patients with advanced HIV (CD4<100/mm3)
- The most common manifestation is meningoencephalitis
- Pulmonary and/or disseminated disease may occur
- Cutaneous cryptococcosis considered as a marker of disseminated disease
- Rapid onset of multiple widespread papular lesions with central umbilication
- Diagnostic clue is the presence of a small area of central hemorrhage or necrosis
- Resembles molluscum contagiosum
- Most common areas affected are head and neck
- Disseminated infections can affect liver, lymph nodes, peritoneum, adrenal gland, and eyes
DD:
- Basal cell carcinoma
- Single, pink, flesh-colored papules
- Arise slowly