Osteosarcoma risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammadmain Rezazadehsaatlou[2].
Overview
Common risk factors in the development of osteosarcoma are radiation to bones, alkylating antineoplastic agents, Paget disease, multiple hereditary osteochondromas, fibrous dysplasia, Bloom syndrome,Rothmund-Thomson syndrome, and Li-Fraumeni syndrome.
Risk Factors [1][2][3][4]
The most common risk factors for osteosarcoma include:
- Teenage growth spurts
- Being tall
- Previous treatment with radiation for another cancer, especially at a young age or with high doses of radiation
- Drugs: past treatment with anticancer drugs called alkylating antineoplastic agents
- Presence of certain benign (noncancerous) bone diseases, such as:
- Paget disease of bone
- Multiple hereditary osteochondromas
- Fibrous dysplasia
- Enchondromtosis
- Presence of certain rare, inherited disorders, such as:
- Bloom syndrome
- Diamond-Blackfan anemia
- Familial adenomatous polyposis
- Li-Fraumeni syndrome
- Hereditary retinoblastoma
- Rothmund-Thomson syndrome
- Werner syndrome
References
- ↑ Stern N, Sakji I, Defachelles AS, Lervat C, Ryckewaert T, Marliot G, Peugniez C, Deplanque D, Penel N (March 2017). "[Incidence and risk factors for ifosfamide-related encephalopathy in sarcoma patients]". Bull Cancer (in French). 104 (3): 208–212. doi:10.1016/j.bulcan.2016.11.007. PMID 27986268.
- ↑ Endicott AA, Morimoto LM, Kline CN, Wiemels JL, Metayer C, Walsh KM (June 2017). "Perinatal factors associated with clinical presentation of osteosarcoma in children and adolescents". Pediatr Blood Cancer. 64 (6). doi:10.1002/pbc.26349. PMID 27860191.
- ↑ Miller BJ, Cram P, Lynch CF, Buckwalter JA (July 2013). "Risk factors for metastatic disease at presentation with osteosarcoma: an analysis of the SEER database". J Bone Joint Surg Am. 95 (13): e89. doi:10.2106/JBJS.L.01189. PMC 3689260. PMID 23824394.
- ↑ Zhang HF, Yan JP, Zhuang YS, Han GQ (September 2015). "Association between angiogenic growth factor genetic polymorphisms and the risk of osteosarcoma". Genet. Mol. Res. 14 (3): 10524–9. doi:10.4238/2015.September.8.14. PMID 26400284.