Amyloidosis epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]

Overview

The incidence of amyloidosis is approximately 1.2 per 100,000 individuals per year worldwide. The prevalence of AL amyloidosis increased significantly between 2007 and 2015, from 1.6 per 100,000 in 2007 to 4.0 per 100,000 in 2015. The mortality rate of systemic amyloidosis is approximately 100 per 100,000 deaths in developed countries. In amyloidosis, the mean age of presentation is 55-60 years. Men are more commonly affected by amyloidosis than women.

Epidemiology and Demographics

Incidence

• The incidence of amyloidosis is approximately 1.2 per 100,000 individuals per year worldwide.
• The incidence of AL amyloidosis ranged from 1 per 100,000 to 1.4 per 100,000 from 2007 to 2015.

Prevalence

• The prevalence of AL amyloidosis increased significantly between 2007 and 2015, from 1.6 per 100,000 in 2007 to 4.0 per 100,000 in 2015.

Mortality rate

• The mortality rate of systemic amyloidosis is approximately 100 per 100,000 deaths in developed countries.

Age

• In amyloidosis, the mean age of presentation is 55-60 years.

Race

• Hereditary amyloidosis subtypes include a substitution of an amino acid that is detected in approximately 4% of the black population.

Gender

• Men are more commonly affected by amyloidosis than women.