Cardiac amyloidosis epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]; Raviteja Guddeti, M.B.B.S. [3]
Epidemiology and Demographics
Age
- In the United States, 1.3 million gene carries have been reported with an approximate 150,000 over the age of 60 years.
- Cardiac amyloidosis commonly presents in adults more than 40 years old. Senile type of cardiac amyloidosis presents after 60 years of age, most commonly after 70 years of age.
- Various mutations of proteins involved in amyloid deposition may present anytime between 30 to 70 years of age.
Ethnicity
- 3-4% of African-Americans carry the most common mutation that causes the substitution of Ile for Val at position [1] and is known to contribute to the incidence of familial amyloidotic cardiomyopathy.[2]
- After the age of 60, isolated cardiac amyloidosis is four times more common among blacks than whites in the United States.[3]
Gender
- There is no difference in the incidence of cardiac amyloidosis between men and women as it affects both genders equally.
References
- ↑ Dictor M, Hasserius R (1981). "Systemic amyloidosis and non-hematologic malignancy in a large autopsy series". Acta Pathologica Et Microbiologica Scandinavica. Section a, Pathology. 89 (6): 411–6. PMID 6278822. Unknown parameter
|month=ignored (help);|access-date=requires|url=(help) - ↑ Jacobson DR, Pastore R, Pool S, Malendowicz S, Kane I, Shivji A, Embury SH, Ballas SK, Buxbaum JN (1996). "Revised transthyretin Ile 122 allele frequency in African-Americans". Human Genetics. 98 (2): 236–8. PMID 8698351. Retrieved 2012-02-13. Unknown parameter
|month=ignored (help) - ↑ Jacobson DR, Pastore RD, Yaghoubian R, Kane I, Gallo G, Buck FS, Buxbaum JN (1997). "Variant-sequence transthyretin (isoleucine 122) in late-onset cardiac amyloidosis in black Americans". The New England Journal of Medicine. 336 (7): 466–73. doi:10.1056/NEJM199702133360703. PMID 9017939. Retrieved 2012-02-13. Unknown parameter
|month=ignored (help)