Dressler's syndrome

Jump to navigation Jump to search

WikiDoc Resources for Dressler's syndrome

Articles

Most recent articles on Dressler's syndrome

Most cited articles on Dressler's syndrome

Review articles on Dressler's syndrome

Articles on Dressler's syndrome in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Dressler's syndrome

Images of Dressler's syndrome

Photos of Dressler's syndrome

Podcasts & MP3s on Dressler's syndrome

Videos on Dressler's syndrome

Evidence Based Medicine

Cochrane Collaboration on Dressler's syndrome

Bandolier on Dressler's syndrome

TRIP on Dressler's syndrome

Clinical Trials

Ongoing Trials on Dressler's syndrome at Clinical Trials.gov

Trial results on Dressler's syndrome

Clinical Trials on Dressler's syndrome at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Dressler's syndrome

NICE Guidance on Dressler's syndrome

NHS PRODIGY Guidance

FDA on Dressler's syndrome

CDC on Dressler's syndrome

Books

Books on Dressler's syndrome

News

Dressler's syndrome in the news

Be alerted to news on Dressler's syndrome

News trends on Dressler's syndrome

Commentary

Blogs on Dressler's syndrome

Definitions

Definitions of Dressler's syndrome

Patient Resources / Community

Patient resources on Dressler's syndrome

Discussion groups on Dressler's syndrome

Patient Handouts on Dressler's syndrome

Directions to Hospitals Treating Dressler's syndrome

Risk calculators and risk factors for Dressler's syndrome

Healthcare Provider Resources

Symptoms of Dressler's syndrome

Causes & Risk Factors for Dressler's syndrome

Diagnostic studies for Dressler's syndrome

Treatment of Dressler's syndrome

Continuing Medical Education (CME)

CME Programs on Dressler's syndrome

International

Dressler's syndrome en Espanol

Dressler's syndrome en Francais

Business

Dressler's syndrome in the Marketplace

Patents on Dressler's syndrome

Experimental / Informatics

List of terms related to Dressler's syndrome

For patient information click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdelrahman Ibrahim Abushouk, MD[2]; Mohammed A. Sbeih, M.D.[3]; Cafer Zorkun, M.D., Ph.D. [4]; Nabeel Ahmed, M.B.B.S

WikiDoc Resources for Dressler's syndrome

Articles

Most recent articles on Dressler's syndrome

Most cited articles on Dressler's syndrome

Review articles on Dressler's syndrome

Articles on Dressler's syndrome in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Dressler's syndrome

Images of Dressler's syndrome

Photos of Dressler's syndrome

Podcasts & MP3s on Dressler's syndrome

Videos on Dressler's syndrome

Evidence Based Medicine

Cochrane Collaboration on Dressler's syndrome

Bandolier on Dressler's syndrome

TRIP on Dressler's syndrome

Clinical Trials

Ongoing Trials on Dressler's syndrome at Clinical Trials.gov

Trial results on Dressler's syndrome

Clinical Trials on Dressler's syndrome at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Dressler's syndrome

NICE Guidance on Dressler's syndrome

NHS PRODIGY Guidance

FDA on Dressler's syndrome

CDC on Dressler's syndrome

Books

Books on Dressler's syndrome

News

Dressler's syndrome in the news

Be alerted to news on Dressler's syndrome

News trends on Dressler's syndrome

Commentary

Blogs on Dressler's syndrome

Definitions

Definitions of Dressler's syndrome

Patient Resources / Community

Patient resources on Dressler's syndrome

Discussion groups on Dressler's syndrome

Patient Handouts on Dressler's syndrome

Directions to Hospitals Treating Dressler's syndrome

Risk calculators and risk factors for Dressler's syndrome

Healthcare Provider Resources

Symptoms of Dressler's syndrome

Causes & Risk Factors for Dressler's syndrome

Diagnostic studies for Dressler's syndrome

Treatment of Dressler's syndrome

Continuing Medical Education (CME)

CME Programs on Dressler's syndrome

International

Dressler's syndrome en Espanol

Dressler's syndrome en Francais

Business

Dressler's syndrome in the Marketplace

Patents on Dressler's syndrome

Experimental / Informatics

List of terms related to Dressler's syndrome

Synonyms and keywords: Postmyocardial infarction syndrome; PMIS; Post-cardiac injury syndrome

Overview

Dressler's syndrome or post myocardial infarction syndrome is a form of pericarditis that occurs in the setting of injury to the heart as a result of myocardial infarction. Dressler's syndrome typically occurs 2 to 10 weeks after myocardial infarction. This differentiates Dressler's syndrome from the much more common post myocardial infarction pericarditis which occurs between days 2 and 4 after myocardial infarction.

Historical Perspective

  • Dressler's syndrome was first characterized by William Dressler in 1956.
  • It should not be confused with the Dressler's syndrome of hemoglobinuria, named after Lucas Dressler who characterized it in 1854.[1][2][3]

Classification

  • There is no established system for the classification of Dressler's syndrome.

Pathophysiology

Gross Pathology


Image courtesy of Professor Peter Anderson, DVM PhD. Published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology[5]

Causes

The common causes of Dressler's syndrome include:

Differentiating Dressler's Syndrome from other Diseases

Dressler's syndrome typically occurs 2 to 10 weeks after a myocardial infarction has occurred.[6][7] This differentiates Dressler's syndrome from

Further, Dressler's syndrome should be differentiated from:

Epidemiology and Demographics

  • Incidence: In the setting of myocardial infarction, Dressler's syndrome occurs in about 3 to 4% of MI cases.[8]
  • Dressler's syndrome was more commonly seen in the era prior to reperfusion, but its incidence has markedly decreased in the reperfusion era, presumably because of smaller infarct sizes.[9]
  • Age: Dressler's syndrome occurs more often in younger age groups.
  • Gender: There is no gender predilection for Dressler's syndrome.
  • Race: There is no racial predilection for Dressler's syndrome.
  • Mortality rate: The mortality rate can reach up to 60% in hospital setting.

Risk Factors

Screening

  • There is insufficient evidence to recommend routine screening for Dressler's syndrome.

Natural History, Complications, and Prognosis

  • Pericardial effusion may result from the accumulation of fluids as a result of inflammation in the pericardial sac.
  • Cardiac tamponade can occur if the accumulation of fluids in the pericardium is large enough and rapid enough.Classic findings of tamponade include Beck's triad:
    • Low blood pressure
    • Distended neck veins (JVD)
    • Muffled/distant heart tones
  • Constrictive pericarditis can occur if there is a chronic inflammatory response

Diagnosis

Symptoms

The syndrome consists of a persistent low-grade fever, and chest pain which is usually pleuritic in nature.The symptoms tend to occur after a few weeks or even months after myocardial infarction and tend to subside in a few days.

Physical Examination

Cardiovascular Examination

  • A pericardial friction rub, and /or a pericardial effusion is present.
  • On physical examination, often tachycardic with a pericardial friction rub heard on auscultation. This characteristic pericardial friction rub may disappear.
  •  This can be secondary to either improvement in or worsening of accumulation of pericardial fluid.
  • Additionally, patients may present with pulsus paradoxus (greater than 10 mmHg decrease in blood pressure with inspiration, and decreased pulse amplitude palpated on the radial artery).
  • Some patients with Dressler's syndrome may exhibit signs of pneumonitis (e.g., a cough, decreased oxygen saturation, fever).
  • The pulmonary component to symptoms can be minimal with no pulmonary complaints, ranging all the way to significant respiratory distress with large pleural effusions.

Laboratory Findings

Elevated ESR.

Imaging Findings

  • An echo will allow for evaluation of the pericardial fluid, if present, and help discern the exact cause of reduced cardiac output (i.e., determine whether truly DS or another condition such as congestive heart failure).
  •   An echo will further allow for evaluation of ventricular contractility, in addition to assessment of the potential risk of cardiac tamponade (i.e., if cardiac chambers appear compressed by pericardial fluid). The more pericardial fluid that is accumulated, the easier it is to detect its presence by echocardiography.[10]
  • Whilst definitive evaluation with formal echocardiogram is the gold standard, bedside cardiac ultrasound.
  • If it is difficult to assess the posterior pericardium with an echo, cardiac magnetic resonance imaging (MRI) may employed to determine whether there is an effusion present. In some instances, fluid collections become loculated.[11]
  • A chest x-ray will reveal flattening of the costophrenic angles and be employed if echocardiography is not available enlargement of the cardiac silhouette as a result of both pleural and pericardial effusions.[12]
  • An electrocardiograph (ECG) initially demonstrate ST segment elevation and T-wave inversion, such as with pericarditis. Further inflammation of the myocardium will also result in ST segment elevations. Both electrical alternans (variation in amplitude or directionality of QRS from beat to beat) and/or a low voltage QRS.

Treatment

Medical Therapy

Dressler's syndrome is typically treated with high dose (up to 650 mg PO q 4 to 6 hours) enteric-coated aspirin. Acetaminophen can be added for pain management as this does not affect the coagulation system. Anticoagulants should be discontinued if the patient develops a pericardial effusion.[13]

NSAIDs such as ibuprofen should be avoided in the peri-infarct period as they:

  • Increase the risk of reinfarction
  • Adversely impact left ventricular remodeling
  • Block the effectiveness of aspirin

2013 Revised ACCF/AHA Guidelines for the Management of ST-Elevation Myocardial Infarction =

Management of Pericarditis After STEMI

Class I
"1. Aspirin is recommended for treatment of pericarditis after STEMI.(Level of Evidence: B)"
Class III (Harm)
"1. Glucocorticoids and nonsteroidal antiinflammatory drugs are potentially harmful for treatment of pericarditis after STEMI. (Level of Evidence: B)"
Class IIb
"1. Administration of acetaminophen, colchicine, or narcotic analgesics may be reasonable if aspirin, even in higher doses, is not effective. (Level of Evidence: B)"


References

  1. Template:WhoNamedIt
  2. L. A. Dressler. Ein Fall von intermittirender Albuminurie und Chromaturie. Archiv für pathologische Anatomie und Physiologie und für klinische Medicin, 1854, 6: 264-266.
  3. DRESSLER W (1956). "A post-myocardial infarction syndrome; preliminary report of a complication resembling idiopathic, recurrent, benign pericarditis". J Am Med Assoc. 160 (16): 1379–83. PMID 13306560.
  4. Jerjes-Sánchez C, Ramírez-Rivera A, Ibarra-Pérez C (1996). "The Dressler syndrome after pulmonary embolism". Am J Cardiol. 78 (3): 343–5. PMID 8759817.
  5. http://www.peir.net/
  6. Krainin F, Flessas A, Spodick D (1984). "Infarction-associated pericarditis. Rarity of diagnostic electrocardiogram". N Engl J Med. 311 (19): 1211–4. PMID 6493274.
  7. Krainin F, Flessas A, Spodick D (1984). "Infarction-associated pericarditis. Rarity of diagnostic electrocardiogram". N Engl J Med. 311 (19): 1211–4. PMID 6493274.
  8. Krainin F, Flessas A, Spodick D (1984). "Infarction-associated pericarditis. Rarity of diagnostic electrocardiogram". N Engl J Med. 311 (19): 1211–4. PMID 6493274.
  9. Tofler GH, Muller JE, Stone PH, Willich SN, Davis VG, Poole WK; et al. (1989). "Pericarditis in acute myocardial infarction: characterization and clinical significance". Am Heart J. 117 (1): 86–92. PMID 2643287.
  10. Wessman DE, Stafford CM (March 2006). "The postcardiac injury syndrome: case report and review of the literature". South. Med. J. 99 (3): 309–14. doi:10.1097/01.smj.0000203330.15503.0b. PMID 16553111.
  11. Scarfone RJ, Donoghue AJ, Alessandrini EA (August 2003). "Cardiac tamponade complicating postpericardiotomy syndrome". Pediatr Emerg Care. 19 (4): 268–71. doi:10.1097/01.pec.0000092573.40174.74. PMID 12972828.
  12. Khandaker MH, Espinosa RE, Nishimura RA, Sinak LJ, Hayes SN, Melduni RM, Oh JK (June 2010). "Pericardial disease: diagnosis and management". Mayo Clin. Proc. 85 (6): 572–93. doi:10.4065/mcp.2010.0046. PMC 2878263. PMID 20511488.
  13. Jaworska-Wilczynska M, Abramczuk E, Hryniewiecki T (November 2011). "Postcardiac injury syndrome". Med. Sci. Monit. 17 (11): CQ13–14. doi:10.12659/msm.882029. PMID 22037738.

See also


de:Dressler-Syndrom


Template:WikiDoc Sources