PURSUIT risk score

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Definition and History

The PURSUIT (Platelet glycoprotein IIb/IIIa in Unstable angina: Receptor Suppression Using Integrilin Therapy) risk score was developed in a randomized clinical trial which recruited 9,461 patients and compared eptifibatide (Integrilin) to placebo in the management of Unstable Angina (UA) or Non-ST elevation Myocardial Infarction (NSTEMI).

Function

  • By using multivariate regression analysis, the investigators established seven risk predictors for death and myocardial infarction (MI) in patients with acute coronary syndromes.
  • Five of these risk factors were then combined into a scoring system:
    • Higher age
    • Sex
    • Worst Canadian Cardiovascular Society (CCS) class of angina
    • Signs of heart failure
    • ST-segment depression on the index ECG
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