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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Pernicious anaemia (also called Addison's anemia) is a type of red blood cell disorder caused by impaired vitamin B12 metabolism. Vitamin B12 is primarily absorbed by the parietal cells of gastric mucosa. Red blood cells in this type of anaemia are abnormally large, thus earning the name megaloblastic anaemia. Pernicious anaemia might be caused due to insufficient intake or poor absorption.