Hepatic encephalopathy primary prevention
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
- Usage of lactulose is helpful in prevention of HE in patients with cirrhosis and acute variceal bleeding.[1]
- Lactulose may be effective to prevent of recurrence of hepatic encephalopathy in patients with cirrhosis.[2]
Primary Prevention
- Usage of lactulose is helpful in prevention of hepatic encephalopathy in patients with cirrhosis and acute upper gastrointestinal bleeding.[3][1]
- Lactulose may be effective to prevent of recurrence of hepatic encephalopathy in patients with cirrhosis.[2]
- Usage of lactitol or rifaximin is not effective in the prophylaxis of hepatic encephalopathy during the first month after a transjugular-intrahepatic-portosystemic-shunt (TIPS).[4]
References
- ↑ 1.0 1.1 Sharma P, Agrawal A, Sharma BC, Sarin SK (2011). "Prophylaxis of hepatic encephalopathy in acute variceal bleed: a randomized controlled trial of lactulose versus no lactulose". J Gastroenterol Hepatol. 26 (6): 996–1003. doi:10.1111/j.1440-1746.2010.06596.x. PMID 21129028.
- ↑ 2.0 2.1 Sharma BC, Sharma P, Agrawal A, Sarin SK (2009). "Secondary prophylaxis of hepatic encephalopathy: an open-label randomized controlled trial of lactulose versus placebo". Gastroenterology. 137 (3): 885–91, 891.e1. doi:10.1053/j.gastro.2009.05.056. PMID 19501587.
- ↑ Aires FT, Ramos PT, Bernardo WM (2016). "Efficacy of lactulose in the prophylaxis of hepatic encephalopathy in cirrhotic patients presenting gastrointestinal bleeding". Rev Assoc Med Bras (1992). 62 (3): 243–7. doi:10.1590/1806-9282.62.03.243. PMID 27310548.
- ↑ Riggio O, Masini A, Efrati C, Nicolao F, Angeloni S, Salvatori FM; et al. (2005). "Pharmacological prophylaxis of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt: a randomized controlled study". J Hepatol. 42 (5): 674–9. doi:10.1016/j.jhep.2004.12.028. PMID 15826716.