Fabry's disease causes

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• Fabry's disease is a genetically X - linked inherited disorder due to a mutation in the GLA gene which is responsible for coding lysosomal enzyme alpha galactosidase A.

• The defeciency of the enzyme leads to build of Gb3( Globotriaosylhexidase) in the lysosomes.
• These accumulations in various tissues leads to classic fabry's disease pathology like angiokeratoma, cardiac, renal and blood vessel accumulation.