Turner syndrome historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Akash Daswaney, M.B.B.S[2]
Overview
Turner syndrome was first described in 1938 by Henry Turner when he noticed a triad of short stature, cubitus valgus and pterygium colli. Other scientists went to to discover the pathophysiology of the 45 XO karyotype and the presence of streaked ovaries.
Historical Perspective
- Turner syndrome was first described by Henry Turner, an Oklahoma endocrinologist in 1938 as a patient with short stature, sexual infantilism, cubitus valgus and pterygium colli. "Turner Syndrome - StatPearls - NCBI Bookshelf".
- Ulrich (in 1930) and Bonnevie (in 1934) described similar findings in a young girl and mouse.
- Ovarian failure and streaked gonads were noted in 1944 by Henry Silver and Kaiser who found elevated gonadotrophins in a 32 month old child. "OVARIAN AGENESIS (CONGENITAL APLASTIC OVARIES) IN CHILDREN | JAMA Pediatrics | JAMA Network".
- C.E Ford et al first described the pathophysiology of 45 XO in 1959 at Harwell, Oxfordshire and Guy's Hospital in London.[2] It was found in a 14-year-old girl with signs of Turner syndrome. [1]
References
- ↑ Lowenstein EJ, Kim KH, Glick SA (2004). "Turner's syndrome in dermatology". J Am Acad Dermatol. 50 (5): 767–76. doi:10.1016/j.jaad.2003.07.031. PMID 15097963.