Thin basement membrane disease
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: Thin membrane nephropathy; thin GBM nephropathy; thin GBM syndrome
Overview
Thin basement membrane disease is one of the inherited disorder of kidney affecting glomeruli. It is also known as Thin basement membrane nephropathy (TBMN) or Benign familial hematuria. . Being the frequent cause of familial hematuria TBMN is affecting 1% of population.[1] 40% of TBMN is caused by germline mutation in COL4A3, COL4A4 genes, but female carrier with COL4A5 mutation may develop TBMN. [2]
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Pathophysiology
Causes
Differentiating Thin basement membrane disease from other Diseases
Epidemiology and Demographics
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Natural History, Complications and Prognosis
Diagnosis
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Template:WH Template:WikiDoc Sources
- ↑ Savige J, Rana K, Tonna S, Buzza M, Dagher H, Wang YY (October 2003). "Thin basement membrane nephropathy". Kidney Int. 64 (4): 1169–78. doi:10.1046/j.1523-1755.2003.00234.x. PMID 12969134.
- ↑ Buzza M, Wilson D, Savige J (May 2001). "Segregation of hematuria in thin basement membrane disease with haplotypes at the loci for Alport syndrome". Kidney Int. 59 (5): 1670–6. doi:10.1046/j.1523-1755.2001.0590051670.x. PMID 11318937.