Thin basement membrane disease other diagnostic studies
|
Thin basement membrane disease Microchapters |
|
Differentiating Thin basement membrane disease from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Thin basement membrane disease other diagnostic studies On the Web |
|
American Roentgen Ray Society Images of Thin basement membrane disease other diagnostic studies |
|
FDA on Thin basement membrane disease other diagnostic studies |
|
CDC on Thin basement membrane disease other diagnostic studies |
|
Thin basement membrane disease other diagnostic studies in the news |
|
Blogs on Thin basement membrane disease other diagnostic studies |
|
Directions to Hospitals Treating Thin basement membrane disease |
|
Risk calculators and risk factors for Thin basement membrane disease other diagnostic studies |
Overview
Heterozygous mutation in COL4A3 and COL4A4 gene is responsible for causing autosomal dominant pattern of 40-50% of Thin basement membrane disease in which people have defective alpha 3, alpha 4 , alpha 5 chains. [1] And heterozygous mutation in COL4A5 gene in X-chromosome may cause Thin basement mamebrane disease in female.
Genetic analysis
- DNA sequencing of COL4A3,COL4A4, COL4A5 is needed for differentiating TBMD and Alport syndrome in specialized laboratory. [2]
References
- ↑ Miner JH (May 2012). "The glomerular basement membrane". Exp. Cell Res. 318 (9): 973–8. doi:10.1016/j.yexcr.2012.02.031. PMC 3334451. PMID 22410250.
- ↑ "Thin Basement Membrane Nephropathy | American Society of Nephrology".