Menopause laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Rahmah Al-Edresi, M.D.[2]
Overview
Laboratory findings consistent with the diagnosis of menopause include elevated Follicle Stimulating Hormone greater than 40 mIU/mL , and a decreased serum of the Anti-Mullerian Hormone level is a diagnostic test of premature menopause.
laboratory findings
Natural menopause:
- An elevated serum of Follicle Stimulating Hormone (FSH) greater than 40 mIU/mL is diagnostic of menopause.[1]
- An elevated FSH level on two blood samples is diagnostic of premature menopause with intervals of about 4–6 weeks between samples
- A decreased serum of the AMH is normal in the postmenopause period.[2]
- A decreased of estrogen Hormone level in women with menopause.
Premature menopause:
- A decreased serum of the Anti-Mullerian Hormone level (AMH) is a diagnostic test of premature menopause
- karyotype analysis and testing for an FMR1 for Fragile X syndrome.
- Decrease of Thyroid-stimulating hormone (TSH)[3]
References
- ↑ Burger HG (1994). "Diagnostic role of follicle-stimulating hormone (FSH) measurements during the menopausal transition--an analysis of FSH, oestradiol and inhibin". Eur J Endocrinol. 130 (1): 38–42. doi:10.1530/eje.0.1300038. PMID 8124478.
- ↑ Visser JA, Schipper I, Laven JS, Themmen AP (2012). "Anti-Müllerian hormone: an ovarian reserve marker in primary ovarian insufficiency". Nat Rev Endocrinol. 8 (6): 331–41. doi:10.1038/nrendo.2011.224. PMID 22231848.
- ↑ Torrealday S, Kodaman P, Pal L (2017). "Premature Ovarian Insufficiency - an update on recent advances in understanding and management". F1000Res. 6: 2069. doi:10.12688/f1000research.11948.1. PMC 5710309. PMID 29225794.