Primary ciliary dyskinesia differential diagnosis

link=https://www.wikidoc.org/index.php/Primary ciliary dyskinesia

Template:Atherosclerosis Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Hafsa Ghaffar, M.B.B.S[2]

Overview

Primary ciliary dyskinesia must be differentiated from other conditions that cause infertility, sinusitis, otitis media, and rhinitis.

Differentiating [Disease name] from other Diseases

Differentiating primary ciliary dyskinesia from other diseases on the basis of [symptom 1], [symptom 2], and [symptom 3]

primary ciliary dyskinesia should be differentiated from other diseases that cause rhinosinusitis, otitis media, and infertility.

• Cystic fibrosis
• Alpha1 antitrypsin deficiency
• Allergic bronchopulmonary aspergillosis.
• Foreign body aspiration
• Immunosuppression.

On the basis [symptom 1], [symptom 2], and [symptom 3], [disease name] must be differentiated from [disease 1], [disease 2], [disease 3], [disease 4], [disease 5], and [disease 6].

Diseases		Clinical manifestations				Para-clinical findings			Gold standard
		Symptoms		Physical examination
						Lab Findings	Imaging
	Age Of Onset	nasal discharge	cough	wheeze	jaundice	Blood levels	Xray chest	CT scan
Cystic fibrosis.	Infancy	+	+	+	-	-	Hyperinflation, Peri bronchial thickening	Not indicated.	Genotyping CFTR gene mutation. Sweat chloride test.
Alpha1-Antitrypsin (AAT) Deficiency	40-50	_	+	+	+	decreased AAT levels	Hyper lucency in lungs.	-	Blood test.
Allergic Broncho pulmonary aspergillosis.	40-50	-	+	+	-	Eosinophilia.	Round mass with air-crescent sign.	Aspergilloma on CT chest.	Sputum analysis. Lung biopsy for fungal culture
Diseases	cough	nasal discharge		wheeze		Lab 1	X-ray	CT scan	Gold standard
Immunodeficiency.

References

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