Pyonephrosis overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Harsh Vardhan Chawla, M.B.B.S.[2]
Overview
Pyonephrosis (Greek pyon "pus" + nephros "kidney") is an infection of obstructed renal collecting system leading to accumulation of pus in the renal collecting system. Pus collects in the renal pelvis and eventually causes destruction of the renal parenchyma[1]. Pyonephrosis is sometimes a complication of renal stones, which can be a source of persisting infection. It may also occur spontaneously.
It needs an early diagnosis and immediate intervention as it may progress to Urosepsis. Treatment may require drainage, best performed by nephrostomy.
Pathophysiology
Pyonephrosis can be seen as a complication of acute pyelonephritis, usually seen with complete or incomplete obstruction of tubules. Obstruction of ureter and renal pelvis causes dilatation of tubular system which in turn leads to hydronephrosis. The dilatation of the tubular system serves as a nidus for infection because the pathogens multiply easily in obstructed and dilated tubules leading to suppurative inflammation.
Causes
Pyonephrosis is commonly caused by bacteria such as Enterococcus spp., K. pneumoniae, Candida spp., S. aureus, P. mirabilis, P. aeruginosa and Group B Streptococcus. The accumulation of pus combined with inability to drain due to obstruction results in pyonephrosis. Risk factors include immunosuppression, local factors of the genitourinary tract like nephrolithiasis, pregnancy, tumors etc.
Epidemiology and Demographics
Although an uncommon condition overall, pyonephrosis has been reported in neonates, children, as well as adults, indicating it can develop in any age group.
Risk Factors
Natural History, Complications, and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
CT scan
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Treatment
Surgery
Primary Prevention
Secondary Prevention
Reference
- ↑ Rojas-Moreno, Christian (2016). "Pyonephrosis and pyocystis". IDCases. 6: 104–105. doi:10.1016/j.idcr.2016.10.005. ISSN 2214-2509.